Scientists reveal how epigenetic changes in DNA are interpreted

A new study in Science from Karolinska Institutet maps out how different DNA-binding proteins in human cells react to certain biochemical modifications of the DNA molecule. The scientists report that some 'master' regulatory ...

New genes linked with bigger brains identified

A number of new links between families of genes and brain size have been identified by UK scientists, opening up a whole new avenue of research to better understand brain development and diseases like dementia.

Newly discovered gene critical to embryo's first days

A previously unknown gene plays a critical part in the development of the human embryo during the first days of fertilisation, researchers from Karolinska Institutet show. The paper, which is published in the scientific journal ...

New insights into early human embryo development

Researchers at Karolinska Institutet and the Ludwig Cancer Research in Stockholm, Sweden have conducted a detailed molecular analysis of the embryo's first week of development. Their results show that there are considerable ...

DNA breaks in nerve cells' ancestors cluster in specific genes

The genome of developing brain cells harbors 27 clusters or hotspots where its DNA is much more likely to break in some places than others, researchers from the Program in Cellular and Molecular Medicine (PCMM) at Boston ...

True love: How transcription factors interact to create a heart

Scientists at the Gladstone Institutes have discovered that three transcription factors—proteins that direct gene expression—interact with each other and the genome to influence how a heart forms in an embryo. Without ...

Mother controls embryo's gene activity

Frog embryos do not fully control which genes they can turn on or off in the beginning of their development – but their mother does, through specific proteins in the egg cell. Molecular developmental biologists at Radboud ...

TOPLESS plants provide clues to human molecular interactions

Scientists at Van Andel Research Institute (VARI) have revealed an important molecular mechanism in plants that has significant similarities to certain signaling mechanisms in humans, which are closely linked to early embryonic ...

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