Structural biology: Mechanisms of novel anti-cancer drugs elucidated

Double-stranded breaks (DSBs) are among the most hazardous forms of DNA damage. The checkpoint protein kinase ATM plays a key role in the repair of DSBs. Many anti-tumor drugs act by inducing DSB formation, so inhibition ...

New nanomaterial for treatment of skin infections

Researchers at the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague) and the Technical University of Liberec in collaboration with researchers from the Institute of Microbiology of the CAS, the Department ...

When organoids meet coronaviruses

Researchers from the group of Hans Clevers in collaboration with the group of Bart Haagmans (Erasmus MC) established an organoid biobank to search for the genes that are essential for the spreading of a SARS-CoV2 infection. ...

Toward one drug to treat all coronaviruses

Safe and effective vaccines offer hope for an end to the COVID-19 pandemic. However, the possible emergence of vaccine-resistant SARS-CoV-2 variants, as well as novel coronaviruses, make finding treatments that work against ...

A machine learning model behind COVID-19 vaccine development

When starting a vaccine program, scientists generally have anecdotal understanding of the disease they're aiming to target. When COVID-19 surfaced over a year ago, there were so many unknowns about the fast-moving virus that ...

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