Tags on RNA silence X chromosome in females

The addition of a chemical tag on an RNA molecule is the critical switch that inactivates one X chromosome in every cell, ensuring healthy development in all female mammals, according to new research by Weill Cornell Medicine ...

How an RNA gene silences a whole chromosome

Researchers at Caltech have discovered how an abundant class of RNA genes, called long non-coding RNAs (lncRNAs, pronounced link RNAs) can regulate key genes. By studying an important lncRNA, called Xist, the scientists identified ...

Calico cats inspire X chromosome research

Calico cats, renowned and beloved for their funky orange and black patchwork or "tortoiseshell" fur, can thank X chromosome inactivation or "silencing" for their unique look.