Hereditary neurodegeneration linked to ADP-ribose modification

Attaching chains of the small molecule ADP-ribose to proteins is important for a cell's survival and the repair of DNA damage, making this process a promising target for the development of new cancer drugs. Researchers have ...

Activating ALC1: With a little help from friends

Chromatin remodeling—the packaging and unpackaging of genomic DNA and its associated proteins—regulates a host of fundamental cellular processes including gene transcription, DNA repair, programmed cell death as well ...

Keeping time: Circadian clocks

Our planet was revolving on its axis, turning night into day every 24 hours, for 4.5 billion years - long before any form of life existed here. About a billion years later, the very first simple bacterial cells came into ...

Solving the mystery of what puts sperm 'in the mood'

In a potential advance toward a male contraceptive pill and new treatments for infertility, researchers are reporting the identification of key biochemical changes that put sperm “in the mood” for fertilization.

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