Chromosomal instability is a phenomenon characterized by rapid changes in the number and structure of chromosomes during cell division. It is very common in solid tumors and it is linked to the aggressive spread of cancer, ...
Cell & Microbiology
Sep 26, 2023
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12
Like a mechanic popping the hood of a car to get at a faulty engine, a tumor-suppressing protein allows cellular repair mechanisms to pounce on damaged DNA by overcoming a barrier to DNA access.
Cell & Microbiology
Jun 19, 2009
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Epithelial cells, which line the surfaces and organs of the body, can protect themselves against cancer by removing unhealthy or abnormal cells through a mechanism known as "apical extrusion," where the damaged cells are ...
Cell & Microbiology
Jul 11, 2022
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62
An animal biologist says poor nutrition results in genetic damage to sperm cells and lower sperm motility for rams.
Plants & Animals
Aug 20, 2014
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0
In studying the impact of DNA damage on the Golgi, a research team from the University of California, San Diego School of Medicine and the Ludwig Institute for Cancer Research have discovered a novel pathway activated by ...
Cell & Microbiology
Jan 30, 2014
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For scientists to improve cancer treatments with targeted therapeutic drugs, they need to be able to see proteins prevalent in the cancer cells. This has been an impossible, until now. Thanks to a new microscopy technique, ...
Analytical Chemistry
Feb 26, 2013
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0
Double-strand breaks (DSBs) are a type of DNA damage where both strands of DNA break at the same location. They can adversely affect cell growth and functioning. Currently, DSBs are detected by immunostaining techniques, ...
Cell & Microbiology
Mar 13, 2023
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3
When cells undergo potentially catastrophic damage, for example as a result of exposure to ionizing radiation, they must make a decision: either to fix the damage or program themselves for death, a process called apoptosis.
Biochemistry
Apr 10, 2009
1
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In this week's issue of Science Signaling (22 January, 2013), Danen and colleagues of the Division of Toxicology of LACDR report novel insights into the question how stem cells decide to commit suicide when their DNA is damaged.
Cell & Microbiology
Jan 23, 2013
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0
DNA damage occurs in all cellular organisms. In human cells, it can be caused by the body's normal metabolic activities, by environmental factors or by chemotherapy. During the crucial phase when cells replicate their genetic ...
Cell & Microbiology
Mar 11, 2019
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