Understanding how autoactivation triggers cell death

Apoptosis is a process that causes cell death. It can go awry in cancer cells, sustaining the disease. Scientists at St. Jude Children's Research Hospital have captured the structure of BAK, a protein that triggers apoptosis. ...

Old protein, new function: tBID can directly trigger cell death

The protein tBID can trigger programmed cell death (apoptosis) by inducing damage in the energy suppliers of the cells, the mitochondria. Apoptosis is essential for maintaining tissue balance. In addition, apoptosis plays ...

Coronaviruses can induce host cell apoptosis

A large team of researchers working at the University of Hong Kong has found that three major types of coronaviruses are able to induce cell apoptosis in infected hosts. In their paper published in the journal Science Advances, ...

New players in the programmed cell death mechanism

Skoltech researchers have identified a set of proteins that are important in the process of apoptosis, or programmed cell death. These newly identified proteins can become targets in the development of drugs against cancer ...

Biochemists discover an enzyme to stop cell death

RUDN biochemists found out that apoptosis (programmed cell death) can be regulated using the EndoG enzyme. The discovery will lead to a better understanding of cell and tissue protection mechanisms. The results of the study ...

How a mitochondrial enzyme can trigger cell death

Cytochrome c is a small enzyme that plays an important role in the production of energy by mitochondria. It is also involved in signaling dangerous problems that warrant apoptosis, or programmed cell death. Using solid-state ...

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