How to find marker genes in cell clusters

Which genes are specific for a certain cell type, i.e., "mark" their identity? With the increasing size of datasets nowadays, answering this question is often challenging. Often, marker genes are simply genes that have been ...

'Nanovaccine' reverses type 1 diabetes in mice

A new study, published online April 8 by Cell Press in the journal Immunity, describes a unique therapeutic "nanovaccine" that successfully reverses diabetes in a mouse model of the disease. In addition to providing new insight ...

Toxoplasmosis—the pathogen with a molecular master key

One of the most widespread zoonoses worldwide, toxoplasmosis is an infectious disease that is caused by the parasite Toxoplasma gondii. Although cats are the final host, the parasite can infest any warm-blooded animal, including ...

Protein essential for maintaining beta cell function identified

Researchers at the Pediatric Diabetes Research Center (PDRC) at the University of California, San Diego School of Medicine have shown that the pancreatic protein Nkx6.1 – a beta-cell enriched transcription factor – is ...

Gifts from the Gila monster

Who would have thought that Gila monster saliva would be the inspiration for a blockbuster new drug for Type 2 diabetes? Or that medicines for chronic pain, heart attacks, high blood pressure and stroke would emerge from ...

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