A bacterial enzyme called histidine kinase is a promising target for new classes of antibiotics. However, it has been difficult to develop drugs that target this enzyme, because it is a "hydrophobic" protein that loses its ...
Biotechnology
Jun 10, 2024
0
17
Many important medicines, such as antibiotics and anticancer drugs, are derived from natural products of bacteria. The enzyme complexes that produce these active ingredients have a modular design that makes them ideal tools ...
Cell & Microbiology
Mar 21, 2024
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51
Slumbering among thousands of bacterial strains in a collection of natural specimens at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, several fragile vials held something unexpected, and ...
Biochemistry
Nov 13, 2023
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201
Enzymes are biological nanomachines. They make almost all of life's chemistry happen, when and where required. Because of their versatility and power, enzymes can be very useful for biotechnology. Taken outside of living ...
Cell & Microbiology
Nov 1, 2023
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29
A diverse set of species, from snails to algae to amoebas, make programmable DNA-cutting enzymes called Fanzors—and a new study from scientists at MIT's McGovern Institute for Brain Research has identified thousands of ...
Molecular & Computational biology
Oct 13, 2023
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6178
Like the human gut, the female genital tract is its own complex microbial ecosystem, where billions of beneficial bacteria make their home. The way Harvard chemist Emily Balskus sees it, the vaginal microbiome is an underappreciated, ...
Cell & Microbiology
Aug 16, 2023
0
5
Bacteria draw from an arsenal of weapons to combat the drugs intended to kill them. Among the most prevalent of these weapons are ribosome-modifying enzymes. These enzymes are growing increasingly common, appearing worldwide ...
Biotechnology
Aug 14, 2023
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8
Pollution of the soil and water with multiple heavy metals is a common problem. However, most studies on the effects of heavy metals on bacteria living in these environments have only focused on one metal at a time. In a ...
Ecology
Mar 6, 2023
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25
Benzobactins are bacterial natural products that have special biological activity due to a compound consisting of two ring structures. The bacterial genes responsible for the formation of the compound were previously unclear. ...
Biochemistry
Nov 18, 2022
0
47
In 2013, a team of microbiologists led by Professor Volker Müller from Goethe University Frankfurt discovered an unusual enzyme in a heat-loving (thermophilic) bacterium: the hydrogen-dependent CO2 reductase HDCR. It produces ...
Cell & Microbiology
Jul 20, 2022
0
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