In research that could one day lead to advances against neurodegenerative diseases like Alzheimer's and Parkinson's, University of Michigan engineering researchers have demonstrated a technique for precisely measuring the ...
Bio & Medicine
Jan 17, 2017
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829
Cambridge researchers have identified - and shown that it may be possible to control - the mechanism that leads to the rapid build-up of the disease-causing 'plaques' that are characteristic of Alzheimer's disease.
General Physics
Jul 18, 2016
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112
(Phys.org) —Mad cow disease and its cousin Creutzfeld-Jakob disease cause fatal spongy changes in brain tissue. Today, we know that these diseases are caused by prions, proteins that are folded incorrectly. A team of German ...
Biochemistry
Aug 16, 2013
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0
X-ray spectromicroscopy at the Scanning X-ray Microscopy beamline (I08), here at Diamond, has been utilised to pinpoint chemically reduced iron and calcium compounds within protein plaques derived from brains of Alzheimer's ...
Bio & Medicine
May 17, 2018
1
187
Nature has many examples of self-assembly, and bioengineers are interested in copying or manipulating these systems to create useful new materials or devices. Amyloid proteins, for example, can self-assemble into the tangled ...
Bio & Medicine
Jan 26, 2015
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728
One of the hallmark traits of Alzheimer's disease, a debilitating disorder marked by memory deficits and general cognitive decline, is the accumulation in the brain of a protein called b-amyloid. These proteins form "plaques" ...
Biochemistry
Oct 23, 2018
0
689
Amyloids refer to abnormal fibrous extracellular and proteinaceous deposits found in organs and tissues that form insoluble constructs that are resistant to degradation. Their formation can accompany disease, where each disease ...
Researchers have shown that aggregation of amyloid-beta, one of two key proteins implicated in Alzheimer's disease, causes cells to overheat and "fry like eggs."
Biochemistry
May 31, 2022
0
252
Amyloidosis is the collective name for a group of diseases characterized by the deposition of amyloids—insoluble proteins that form due to the misfolding and aggregation of soluble proteins—outside of cells. Such depositions ...
Molecular & Computational biology
May 6, 2022
0
7
Scientists at The Scripps Research Institute (TSRI) have developed a broadly useful method to unmask new functional features of human proteins.
Biochemistry
Nov 1, 2016
0
185
