Study probes interplay of proteins in type 2 diabetes

A hallmark of age-related diseases such as Parkinson's disease, type 2 diabetes, or Alzheimer's disease is the abnormal clumping of proteins in cells. In people with these conditions, these protein clumps can result in irregular ...

Chemists discover structure of glucagon fibrils

Patients with type 1 diabetes have to regularly inject themselves with insulin, a hormone that helps their cells absorb glucose from the bloodstream. Another hormone called glucagon, which has the opposite effect, is given ...

Scientists map toxic proteins linked to Alzheimer's

A team of researchers from McMaster University has mapped at atomic resolution a toxic protein linked to Alzheimer's disease, allowing them to better understand what is happening deep within the brain during the earliest ...

Technique uses well-known dye to watch amyloid plaques in the brain

While amyloid plaques have long been closely associated with mechanisms driving Alzheimer's disease, visualizing how amyloid proteins assemble continues to prove difficult. The nanometer-sized amyloid fibrils are only a fraction ...

Protein chains that self-form into helical braids

A team of researchers from Durham University in the U.K. and Shaanxi Normal University in China has discovered a type of protein that forms naturally into two main types of helical braids. In their paper published in the ...

A boundary dance of amyloid-β stepping into dementia

Alzheimer's disease is caused by aggregates of amyloid-β (Aβ) peptides. This aggregation is accelerated at the cell membrane surface. Using molecular dynamics simulations and NMR experiments, the research group at ExCELLS ...

Chemists develop new method for selective binding of proteins

A new method of selectively binding proteins to nanoparticles has been described by a team of German and Chinese researchers headed by Prof. Bart Jan Ravoo, a chemist at the University of Münster (Germany). The nanoparticles ...

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Amyloid

Amyloids are insoluble fibrous protein aggregates sharing specific structural traits. Abnormal accumulation of amyloid in organs may lead to amyloidosis, and may play a role in various neurodegenerative diseases.

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