A research group led by Dr. Tomoaki Murakami from the Tokyo University of Agriculture and Technology has revealed that fibrinogen Aα-chain amyloidosis, a previously unreported disease in animals other than humans, is highly ...
Molecular & Computational biology
Aug 18, 2023
0
65
A team at UT Southwestern has developed a computational approach to uncover mechanisms of protein misfolding linked to neurodegenerative diseases. The study, published in Nature Communications, offers key insights that could ...
Biochemistry
Mar 27, 2023
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19
Researchers at the UAB have determined the structure of amyloid fibers formed by the protein hnRNPDL-2, implicated in limb-girdle muscular dystrophy type 3, using high-resolution cryo-electron microscopy (cryo-EM). They have ...
Biotechnology
Feb 3, 2023
0
68
Scientists from Rice University are using fluorescence lifetime to shed new light on a peptide associated with Alzheimer's disease, which the Centers for Disease Control and Prevention estimates will affect nearly 14 million ...
Biochemistry
Jan 25, 2023
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32
Stains that make specific components of a live cell light up under a microscope have become powerful tools for detecting disease and monitoring biological processes, but the choice of available stains is severely limited ...
Biochemistry
Dec 12, 2022
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48
Neurodegenerative diseases like Alzheimer's disease or Parkinson's disease are caused by folding errors (misfolding) in proteins or peptides, i.e. by changes in their spatial structure. This is the result of minute deviations ...
Biochemistry
Jul 20, 2022
0
15
Protein function and activity are determined by both their assembly and secondary structure. Abnormalities related to either protein aggregation or secondary structure can lead to neurodegenerative diseases. In a new study, ...
Bio & Medicine
Jul 14, 2022
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10
Researchers have shown that aggregation of amyloid-beta, one of two key proteins implicated in Alzheimer's disease, causes cells to overheat and "fry like eggs."
Biochemistry
May 31, 2022
0
252
In a finding that has important ramifications for neurodegenerative disorders such as Alzheimer's disease, RIKEN researchers have discovered how three chaperone molecules in yeast cells work together to break up beta-sheet-rich ...
Biochemistry
May 26, 2022
0
91
Amyloidosis is the collective name for a group of diseases characterized by the deposition of amyloids—insoluble proteins that form due to the misfolding and aggregation of soluble proteins—outside of cells. Such depositions ...
Molecular & Computational biology
May 6, 2022
0
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