The effectiveness of any drug molecule depends on how well it interacts with the internal environment inside our body. Its pharmacokinetic (PK) properties determine how successfully it escapes degrading enzymes as it travels ...
Biochemistry
Oct 10, 2023
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54
Cyclic peptides often exhibit low membrane permeability that can be significantly improved via amide-to-ester substitutions, as demonstrated by researchers from Tokyo Institute of Technology (Tokyo Tech). The utilization ...
Biochemistry
Mar 17, 2023
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65
A high-yield, one-pot, scalable reaction facilitates the production of biologically relevant amide compounds using less reactive nitrogen-containing heterocyclic compounds and carboxylic acid without the use of heat or special ...
Analytical Chemistry
Feb 16, 2023
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37
Linking molecular components through amide bonds is one of the most important reactions in research and the chemical industry. In the journal Angewandte Chemie, scientists have now introduced a new type of reaction for making ...
Materials Science
Jan 27, 2021
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17
Proteins are composed of amino acids connected by amide bonds. The amide bond exhibits high chemical stability and has a planar structure around the bond. Although the high stability of the amide bond is indispensable for ...
Materials Science
Apr 28, 2020
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16
What to do proteins and Kevlar have in common? Both feature long chain molecules that are strung together by amide bonds. These strong chemical bonds are also common to many other naturally occurring molecules as well as ...
Materials Science
May 26, 2017
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5
(PhysOrg.com) -- Researchers in the University of Bristol's School of Chemistry have found a way to accelerate the breakdown of amide bonds.
Materials Science
Dec 16, 2011
0
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