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Bio & Medicine Aug 15, 2023

Programmable DNA hydrogels for advanced cell culture and personalized medicine

In-vitro culture of biological cells plays an important role in advancing biological research. However, currently available cell culture materials have significant drawbacks. Many of them are derived from animal sources, ...

Ecology Aug 14, 2023

Researchers characterize tardigrade species richness in Denmark

They're found on Mount Everest, in the deep seas, aboard the International Space Station and thousands of them have even crash landed and been spilled onto the moon. The microscopic water bear has a nearly unfathomable ability ...

Molecular & Computational biology Aug 9, 2023

The link between the impact of radiation on DNA and the time in which the damaged molecule breaks irreversibly revealed

We are exposed to ionizing radiation more often than we think: when we bathe in the sun, which emits UV rays, or when we get X-rayed. Even when we are traveling on an intercontinental flight, which reaches 10,000 meters above ...

Biochemistry Jul 31, 2023

Researchers use quantum circuit to identify single nucleotides

DNA sequencing technology, i.e., determining the order of nucleotide bases in a DNA molecule, is central to personalized medicine and disease diagnostics, yet even the fastest technologies require hours, or days, to read ...

Bio & Medicine Jul 25, 2023

Machine learning enables discovery of DNA-stabilized silver nanoclusters

DNA can do more than pass genetic code from one generation to the next. For nearly 20 years, scientists have known of the molecule's ability to stabilize nanometer-sized clusters of silver atoms. Some of these structures ...

Cell & Microbiology Jul 24, 2023

Bacterial single-cell, whole-genome sequencing overhauled by engineered polymerase

Sequencing the genome of single bacterial cells has long been technically difficult due to the seemingly unalterable bias in the gene amplification stage of the process, making it hard to produce high-coverage genome sequence ...

Cell & Microbiology Jul 13, 2023

The structure of a protein bound to DNA reveals how the toxicity of the cholera bacterium is activated

Understanding the molecular mechanism that triggers disease is essential for identifying new treatments. Cholera, a disease caused by the bacterium Vibrio cholerae, is no exception.

Biotechnology Jul 13, 2023

Double-stranded DNA donor with novel structure boosts gene knock-in efficiency

A research group led by Prof. Liang Haojun and researcher Bao Jianqiang from the University of Science and Technology of China (USTC) proposed a novel functional double-stranded DNA (dsDNA) donor that greatly enhances the ...

Cell & Microbiology Jul 10, 2023

DNA-repair protein complex is a shapeshifter, reconfiguring itself to meet the demands of each task

Transcription factor IIH, or TFIIH, pronounced "TF two H," is a veritable workhorse among the protein complexes that control human cell activity. It plays critical roles both in transcription—the highly regulated enzymatic ...

Biotechnology Jun 16, 2023

New method can manipulate the shape and packing of DNA

A human cell harbors roughly 2 meters of DNA, encompassing the essential genetic information of an individual. If one were to unwind and stretch out all the DNA contained within a single person, it would span a staggering ...

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