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Evolution Nov 22, 2024

Gene regulation study reports surprising results: Extensive regions of DNA belong to multiple gene switches

Some sequences in the genome cause genes to be switched on or off. Until now, each of these gene switches, or so-called enhancers, was thought to have its own place on the DNA. Different enhancers are therefore separated ...

Biotechnology Nov 11, 2024

New CRISPR system for gene silencing doesn't rely on cutting DNA

Scientists from Vilnius University's (VU) Life Sciences Center (LSC) have discovered a unique way for cells to silence specific genes without cutting DNA. This research, led by Prof. Patrick Pausch and published in the journal ...

Biotechnology Oct 14, 2024

Expansion in situ genome sequencing innovation makes hidden DNA-protein interactions visible

Harvard scientists have unveiled a new technique called expansion in situ genome sequencing (ExIGS) that combines existing in situ genome sequencing (IGS) with expansion microscopy (ExM). The innovation allowed researchers ...

Cell & Microbiology Sep 11, 2024

How proteins bind to closed regions of the genome to facilitate cell differentiation and development

A new experimental method allows researchers to dissect how certain proteins, called pioneer factors, can bind to selective regions of the genome that are inaccessible to other DNA binding proteins.

Biotechnology Sep 10, 2024

Researchers bend DNA strands with light, revealing a new way to study the genome

With the flick of a light, researchers have found a way to rearrange life's basic tapestry, bending DNA strands back on themselves to reveal the material nature of the genome.

Molecular & Computational biology Aug 28, 2024

From decades to days, biophysicists reveal DNA behavior in record time

Studying how single DNA molecules behave helps us to better understand genetic disorders and design better drugs. Until now, however, examining DNA molecules one-by-one was a slow process.

Cell & Microbiology Aug 26, 2024

New genetic sensor for DNA methylation discovered

DNA methylation is a process in which a methyl group is attached to the cytosine base of the DNA molecule, and is a major way that DNA is epigenetically marked. Epigenetic modifications can act as on–off switches to regulate ...

Molecular & Computational biology Aug 16, 2024

DNA study challenges thinking on ancestry of people in Japan

A genetic study led by researchers from RIKEN's Center for Integrative Medical Sciences has uncovered evidence that people in Japan descend from three ancestral groups.

Biotechnology Aug 13, 2024

New genetic editing technique can modify wild populations with less risk

A new technique developed by researchers from Macquarie University and the California Institute of Technology could allow scientists to more safely alter the genetic makeup of wild populations. The study is published in the ...

Molecular & Computational biology Aug 9, 2024

Researchers develop AI model that predicts the accuracy of protein–DNA binding

A new artificial intelligence model developed by USC researchers and published in Nature Methods can predict how different proteins may bind to DNA with accuracy across different types of protein, a technological advance ...

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