Search results for CRISPR-Cas9

Cell & Microbiology Mar 14, 2024

Researchers reveal dual-function mechanism of bacteriophage-derived protein AcrIIA15

In response to the efficient attacks of the host CRISPR-Cas system, bacteriophages have evolved various resistance strategies, including encoding anti-CRISPR (Acr) proteins. Since their initial discovery in 2013, over a hundred ...

Biotechnology Mar 14, 2024

It's hearty, it's meaty, it's mold: Hacking the genome of fungi for smart foods of the future

With animal-free dairy products and convincing vegetarian meat substitutes already on the market, it's easy to see how biotechnology can change the food industry. Advances in genetic engineering are allowing us to harness ...

Cell & Microbiology Mar 13, 2024

Study shows for the first time that different forms of cellular adhesion structures can interconvert

Cells form adhesion structures to anchor themselves in their environment. The coordinated assembly and disassembly of these adhesions also enables cells to move from one place to another.

Bio & Medicine Mar 12, 2024

'GPS nanoparticle' platform precisely delivers therapeutic payload to cancer cells

A newly developed "GPS nanoparticle" injected intravenously can home in on cancer cells to deliver a genetic punch to the protein implicated in tumor growth and spread, according to researchers from Penn State. They tested ...

Biotechnology Mar 7, 2024

CRISPRlnc: New lncRNA-specific SgRNA design method proposed

Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts. Currently, CRISPR/Cas9 is a promising RNA-guided genome editing technology consisting of a Cas9 nuclease and a single-guide RNA (sgRNA). Considering the significant ...

Bio & Medicine Mar 4, 2024

Lipid nanoparticles research closing in on genetic treatments for hereditary lung disease, vision loss

Researchers who work with tiny drug carriers known as lipid nanoparticles have developed a new type of material capable of reaching the lungs and the eyes, an important step toward genetic therapy for hereditary conditions ...

Molecular & Computational biology Feb 27, 2024

Researchers find molecular mechanism that regulates powdery mildew resistance in cucumbers

A team from the department of Cucurbitaceae Vegetable Genetics and Breeding, at the Institute of Vegetables and Flowers (IVF, CAAS) has made important progress in the molecular mechanism of powdery mildew (PM) resistance ...

Molecular & Computational biology Feb 26, 2024

Unlocking the color code: The role of VvBBX44 and VvMYBA1 in regulating grape anthocyanin biosynthesis

Anthocyanins significantly influence grape quality and color, with transcription factors HY5 and MYBA1 playing pivotal roles in their biosynthesis. Recent findings show that VvBBX44, a B-box protein, inhibits anthocyanin ...

Molecular & Computational biology Feb 22, 2024

CRISPR/Cas9-mediated targeted mutagenesis of inulin biosynthesis in rubber dandelion

Researchers have leveraged the power of the CRISPR/Cas9 genome editing system to enhance natural rubber production in rubber dandelion (Taraxacum kok-saghyz). The CRISPR system's efficiency and precision offer a promising ...

Biotechnology Feb 22, 2024

Chromatin accessibility: A new avenue for gene editing

In a study recently published in Nature Genetics, researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University explore chromatin accessibility, i.e., endogenous access pathways to the genomic DNA, and its ...

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