Whitehead Institute researchers have used the gene regulation system CRISPR/Cas to engineer mouse genomes containing reporter and conditional alleles in one step. Animals containing such sophisticated engineered alleles can ...
Cell & Microbiology
Aug 29, 2013
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By creating a powerful new gene regulation system called CRISPR-on, Whitehead Institute researchers now have the ability to increase the expression of multiple genes simultaneously and precisely manipulate each gene's expression ...
Biotechnology
Aug 27, 2013
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By tracking the previously unknown movements of a set of specialized cells, Whitehead Institute scientists are shedding new light on how the immune system mounts a successful defense against hostile, ever-changing invaders.
Cell & Microbiology
Aug 9, 2013
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Painstaking new analysis of the genetic sequence of the X chromosome—long perceived as the "female" counterpart to the male-associated Y chromosome—reveals that large portions of the X have evolved to play a specialized ...
Biotechnology
Jul 21, 2013
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Writing in his journal about the scientists of his era, Henry David Thoreau bemoaned their blindness to significant phenomena: "The question is not what you look at, but what you see." More than 150 years later, his words ...
Cell & Microbiology
Jul 18, 2013
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Whitehead Institute researchers have determined that the transcription factor Nanog, which plays a critical role in the self-renewal of embryonic stem cells, is expressed in a manner similar to other pluripotency markers. ...
Cell & Microbiology
Jul 3, 2013
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Whitehead Institute Founding Member Rudolf Jaenisch, who helped transform the study of genetics by creating the first transgenic mouse in 1974, is again revolutionizing how genetically altered animal models are created and ...
Cell & Microbiology
May 2, 2013
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Whitehead Institute researchers have determined that DNA transcription, the process that produces messenger RNA (mRNA) templates used in protein production, also runs in the opposite direction along the DNA to create corresponding ...
Cell & Microbiology
Feb 4, 2013
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A family of nutrient-sensing enzymes, dubbed Rag GTPases, modulates the activity of the mTORC1 protein complex, whose inhibition is essential for autophagy and survival in newborn mammals. One enzyme, RagA, has been found ...
Cell & Microbiology
Dec 23, 2012
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Several years ago, biologists discovered that regular body cells can be reprogrammed into pluripotent stem cells—cells with the ability to become any other type of cell. Such cells hold great promise for treating many human ...
Cell & Microbiology
Sep 13, 2012
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