Scientists at St. Jude Children's Research Hospital are studying voltage-gated ion channels (VGICs). Their work revealed a previously unknown mechanism of inactivation for one such channel that plays an important role in ...
Cell & Microbiology
May 20, 2022
0
90
Scientists at St. Jude Children's Research Hospital and Columbia University/New York State Psychiatric Institute are studying G protein-coupled receptors (GPCRs), membrane proteins that are the target of one-third of approved ...
Cell & Microbiology
Apr 27, 2022
0
24
Apoptosis is a process that causes cell death. It can go awry in cancer cells, sustaining the disease. Scientists at St. Jude Children's Research Hospital have captured the structure of BAK, a protein that triggers apoptosis. ...
Cell & Microbiology
Jan 11, 2022
0
91
Immunologists at St. Jude Children's Research Hospital have identified biochemical "switches" that control development of regulatory T cells and offer a novel strategy for treatment of autoimmune diseases and cancer. The ...
Cell & Microbiology
Dec 29, 2021
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287
CTCF is a transcription factor that has been a research target due to its role in regulating a critical oncogene called MYC. Scientists at St. Jude Children's Research Hospital have found direct evidence that CTCF governs ...
Cell & Microbiology
Sep 7, 2021
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39
About 95% of all crystal structures obtained for various proteins and deposited in public databases are captured using cryogenic technology. This technology requires frozen conditions. Scientists at St. Jude Children's Research ...
Biochemistry
Aug 19, 2021
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419
Scientists at St. Jude Children's Research Hospital are studying liquid-liquid phase separation (LLPS), a biophysical process through which proteins and nucleic acids in a cell are compartmentalized without a membrane. The ...
Biochemistry
Jul 26, 2021
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240
St. Jude Children's Research Hospital scientists have used single-molecule fluorescence resonance energy transfer (smFRET) and cryogenic electron microscopy (cryo-EM) to capture six new structures of the ribosome and its ...
Molecular & Computational biology
Jul 8, 2021
0
14
Scientists at St. Jude Children's Research Hospital have developed an easy to use, sensitive and high-throughput method to define sites of unintended double stranded breaks in DNA caused by genome editors like the CRISPR-Cas9 ...
Biotechnology
Jun 16, 2020
0
18
St. Jude Children's Research Hospital investigators are studying the details of how phase separation leads to the formation of RNA granules, assemblies of protein and RNA that are not bound by a membrane. Their findings show ...
Cell & Microbiology
Apr 17, 2020
0
133
