Massachusetts General Hospital (MGH) investigators have developed a method of detecting, across the entire genome of human cells, unwanted DNA breaks induced by use of the popular gene-editing tools called CRISPR-Cas RNA-guided ...
Biotechnology
Dec 16, 2014
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The same research team that developed the first laser based on a living cell has shown that use of fluorescent proteins in a solid form rather than in solution greatly increases the intensity of light produced, an accomplishment ...
Optics & Photonics
Dec 8, 2014
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Artificially stimulating a brain region believed to play a key role in learning, reward and motivation induced monkeys to change which of two images they choose to look at. In experiments reported online in the journal Current ...
Plants & Animals
May 29, 2014
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A next-generation genome editing system developed by Massachusetts General Hospital (MGH) investigators substantially decreases the risk of producing unwanted, off-target gene mutations. In a paper receiving online publication ...
Biotechnology
Apr 25, 2014
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A simple adjustment to a powerful gene-editing tool may be able to improve its specificity. In a report receiving advance online publication in Nature Biotechnology, Massachusetts General Hospital (MGH) investigators describe ...
Biotechnology
Jan 26, 2014
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A team of Massachusetts General Hospital (MGH) investigators working to create "protocells" – primitive synthetic cells consisting of a nucleic acid strand encased within a membrane-bound compartment – have accomplished ...
Biotechnology
Nov 28, 2013
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In the past year a group of synthetic proteins called CRISPR-Cas RNA-guided nucleases (RGNs) have generated great excitement in the scientific community as gene-editing tools. Exploiting a method that some bacteria use to ...
Biotechnology
Jun 23, 2013
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A handheld diagnostic device that Massachusetts General Hospital (MGH) investigators first developed to diagnose cancer has been adapted to rapidly diagnose tuberculosis (TB) and other important infectious bacteria. Two papers ...
Bio & Medicine
May 5, 2013
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Two Massachusetts General Hospital (MGH)-based research teams, along with a group from the University of California at San Diego, have discovered that animals have a previously unknown system for detecting and responding ...
Cell & Microbiology
Apr 12, 2012
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Development of a new way to make a powerful tool for altering gene sequences should greatly increase the ability of researchers to knock out or otherwise alter the expression of any gene they are studying. The new method ...
Biotechnology
Apr 9, 2012
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