Fast-mutating DNA sequences shape early development

What does it mean to be human? According to scientists the key lies, ultimately, in the billions of lines of genetic code that comprise the human genome. The problem, however, has been deciphering that code. But now, researchers ...

Mutant stem cells defy rules of development

Imagine you're baking a cake, but you run out of salt. Even with the missing ingredient, the batter still looks like cake batter, so you stick it in the oven and cross your fingers, expecting to end up with something pretty ...

Unearthing the secrets of cellular energy

Everything the body does—your brain thinking, your heart beating, your cells growing—requires energy. Consequently, it comes as no surprise that disruptions in energy production can contribute to a wide range of diseases. ...

Cellular energy audit reveals energy producers and consumers

Adenosine triphosphate, or ATP, is the cellular energy currency that is as valuable to the human body as the dollar is to the US economy. Too high or too low levels of ATP in some cell types have been linked to a variety ...

Study suggests catalyst for human brain evolution

More than a million years ago, large chunks of the human genome were rearranged—a chance event during egg or sperm formation that led to the deletion, duplication, or reversal of sections of DNA. Those structural variants, ...

Researchers pioneer new method to edit genes in human cells

Over the past decade, the CRISPR genome-editing system has revolutionized molecular biology, giving scientists the ability to alter genes inside living cells for research or medical applications. Now, researchers at Gladstone ...

Key innovations in stem-cell technology will advance medicine

A scientist at the Gladstone Institutes has made two significant stem-cell discoveries that advance medicine and human health by creating powerful new approaches for using stem cells and stem-cell-like technology.

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