The Friedrich Miescher Institute for Biomedical Research (FMI) is part of the Novartis Research Foundation and is a world-class center for basic research in life sciences based in Basel, Switzerland. The FMI is devoted to the pursuit of fundamental biomedical research. Areas of expertise are: In these fields the FMI has gained international recognition as a center of excellence in innovative biomedical research. Research is carried out in 22 independent but highly interactive research teams. In addition, seven technology platforms, ranging from functional genomics to microscopy and imaging, support the research activities with cutting-edge technology. As of 2011, the institute counts 320 collaborators of which 90 are postgraduate students participating in the FMI International PhD Program, 100 are postdoctoral collaborators and 22 are research group leaders. Since 2004, the institute is led by Susan M. Gasser. in chronological order The FMI is an affiliated institute of the University of Basel. It provides biomedical research and career training for over 90 PhD students. FMI selects its highly international student body during a twice-yearly interview-based selection program.

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The hidden treasure in RNA-seq

Michael Stadler and his team at the Friedrich Miescher institute for Biomedical Research (FMI) have developed a novel computational approach to analyze RNA-seq data. By comparing intronic and exonic RNA reads, this approach ...

The neuronal mechanism behind motivation

Our actions are motivated by the goals we want to achieve. However, little is known about the mechanism in our brains that allow us to make the right decisions to reach our goals. Researchers in the Lüthi lab now identified ...

Cellular memory of stressful situations

Stress is unhealthy. The cells use therefore a variety of mechanisms to deal with stress and avert its immediate threat. However, certain stressful situations leave marks that go beyond the immediate response; some even seem ...

New insights into cooperativity in gene regulation

In a study published in Nature, Dirk Schübeler and his group at the Friedrich Miescher Institute for Biomedical Research (FMI) describe how the interplay between transcription factors and epigenetic modifications of DNA ...

How animals reach their correct size

Even small differences in how fast animals grow during development can sum up to large differences in their adult body size. Nevertheless, adults of the same species are usually nearly identical in size. Benjamin Towbin, ...

Epigenetic repression suppresses genomic instability

Susan Gasser and her group at the FMI have found the pathway through which eukaryotic organisms protect their genomes from rearrangements and deletions that arise from repetitive DNA. Human genomes, like those of simple animals ...

How genes are permanently silenced by small RNAs

Marc Bühler and his team at the Friedrich Miescher Institute for Biomedical Research (FMI) have elucidated the mechanism underlying small RNA-mediated gene silencing, thus solving a mystery which has been puzzling the research ...

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