Click chemistry: Research team creates 150 new compounds

Cold Spring Harbor Laboratory (CSHL) chemists have created a new collection of molecular compounds and begun testing them as potential leads in the search for new drugs. Among these molecules, they found several that show ...

An evolutionary mystery 125 million years in the making

Plant genomics has come a long way since Cold Spring Harbor Laboratory (CSHL) helped sequence the first plant genome. But engineering the perfect crop is still, in many ways, a game of chance. Making the same DNA mutation ...

How plants pass down genetic memories

When organisms pass their genes on to future generations, they include more than the code spelled out in DNA. Some also pass along chemical markers that instruct cells how to use that code. The passage of these markers to ...

This eight-armed octopus-like pore detects taste

The neurons in our bodies are dotted with tiny pores that let essential molecules pass in and out of our cells. Neurons need these channels to send the signals that allow us to move, think, and perceive the world around us. ...

The digital dark matter clouding AI in genome analysis

Artificial intelligence has entered our daily lives. First, it was ChatGPT. Now, it's AI-generated pizza and beer commercials. While we can't trust AI to be perfect, it turns out that sometimes we can't trust ourselves with ...

New shape-shifting antibiotics could fight deadly infections

In the United States alone, drug-resistant bacteria and fungi infect almost 3 million people per year and kill about 35,000. Antibiotics are essential and effective, but in recent years overuse has led to some bacteria developing ...

A new, sustainable source for a promising cancer killer

Plants produce all types of curious chemicals. Some deter predators. Some smell wonderful. Some even have medicinal value. One of these hidden gems is (–)-jerantinine A (JA), a molecule with remarkable anticancer properties, ...

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