Looking beyond genes to explain blood cells' fates

Scientists often talk about cell fate and commitment in terms of mechanisms that control gene expression (transcription factors, chromatin remodeling, etc.). But by studying Diamond-Blackfan anemia (DBA), rare genetic blood ...

Evolving a more versatile CRISPR-Cas9

For all of Cas9's potential in research and therapeutics, it—as well as other enzymes in the CRISPR-associated family—has limitations. In order to recognize and bind to a DNA sequence, Cas9 needs a particular stretch ...

New CRISPR tool targets RNA in mammalian cells

Researchers from the Broad Institute of MIT and Harvard have shown that a CRISPR-based editing system can cut and bind RNA in mammalian cells. In a paper out this week in Nature, the team used CRISPR-Cas13, which the researchers ...

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