China clones gene-edited monkeys to aid disorder research

The Shanghai institute  made news in January 2018 by announcing researchers had cloned the first two monkeys using a process cal
The Shanghai institute made news in January 2018 by announcing researchers had cloned the first two monkeys using a process called somatic cell nuclear transfer, the same method used to produce the celebrated sheep "Dolly" more than 20 years ago 

Chinese scientists announced Thursday they had cloned five monkeys from a single animal that was genetically engineered to have a sleep disorder, saying it could aid research into human psychological problems.

The claim, detailed in two reports published in a Chinese science journal, is the latest in a series of biomedical advances in the country, some of which have fuelled medical ethics debates.

Most recently a Chinese scientist claimed last year he had altered the DNA of babies to make them HIV-proof.

A research team from the Institute of Neuroscience at the Chinese Academy of Sciences in Shanghai said it had altered the genes of a macaque to give it circadian rhythm disorder, in which the body's "clock" is out of sync with normal sleep times.

They went on to clone five macaques from that individual, and found that the new monkeys—born over the past six months—show signs of mental problems associated with sleep disorders including depression, anxiety and behaviours linked to schizophrenia.

The findings, published Thursday in the English-language journal National Science Review, were hailed as a world first by Chinese media.

The report's authors said the findings could aid research into human psychological illnesses because scientists would be able to create animals with specific disorders.

Poo Muming, the director of the neuroscience institute and the study's co-author, told state media the research team would seek to clone more monkeys with different brain in hopes that future experiments on them could yield new drugs or treatment.

He said this could also reduce the overall numbers of healthy macaques that are subjected to experiments around the world, in a boost for animal welfare.

The same Shanghai institute previously made news in January 2018 by announcing researchers had cloned the first two monkeys using a process called somatic cell nuclear transfer.

The method was the same used to produce the celebrated sheep "Dolly" more than 20 years ago.

Other species were subsequently cloned via the method over the years but primates had until last year proven difficult to clone and the team's achievement was hailed as a breakthrough.

But such advancements often stir controversy.

Chinese researcher He Jiankui shocked the after revealing that he had successfully gene-edited twin girls born in November to prevent them from contracting HIV.

He now faces a and has been dismissed from his position at the Southern University of Science and Technology in Shenzhen.


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More information: Qiu, P. et al: "BMAL1 knockout macaque monkeys display reduced sleep and psychiatric disorders". National Science Review. DOI: 10.1093/nsr/nwz002 , https://academic.oup.com/nsr/article-lookup/doi/10.1093/nsr/nwz002

Liu, Z. et al. "Cloning of a gene-edited macaque monkey by somatic cell nuclear transfer ". National Science Review. DOI: 10.1093/nsr/nwz003 , https://academic.oup.com/nsr/article-lookup/doi/10.1093/nsr/nwz003

© 2019 AFP

Citation: China clones gene-edited monkeys to aid disorder research (2019, January 24) retrieved 16 July 2019 from https://phys.org/news/2019-01-china-clones-gene-edited-monkeys-aid.html
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