China orders probe into scientist claims of first gene-edited babies

November 27, 2018 by Helen Roxburgh
CRISPR technology has opened up enormous potential to battle genetic faults and diseases

Beijing has ordered an investigation into claims by a Chinese scientist to have created the world's first genetically-edited babies, a move that would be a ground-breaking medical first but which has generated a barrage of criticism.

A video posted on YouTube by university professor He Jiankui said that the twin girls, born a few weeks ago, had had their DNA altered to prevent them from contracting HIV, prompting a heated debate among the scientific community.

As experts cast doubt over the claimed breakthrough and others decried it as a modern form of eugenics, China's National Health Commission ordered an "immediate investigation" into the case, the official Xinhua news agency reported early Tuesday, citing a statement on the NHC's website.

The professor, who was educated at Stanford University in the US and works from a lab in the southern Chinese city of Shenzhen, said the twins' DNA was modified using CRISPR, a technique which allows to remove and replace a strand with pinpoint precision.

The development emerged Sunday in an article published by industry journal the MIT Technology Review, which referenced medical documents posted online by He's to recruit couples for the experiments.

He said the babies, known as "Lulu" and "Nana" although they are not their real names, were born through regular IVF but using an egg which was specially modified before being inserted into the womb.

"Right after sending her husband's sperm into her egg, an embryologist also sent in CRISPR/Cas9 protein and instructions to perform a gene surgery intended to protect the girls from future HIV infection," he said.

Gene editing is a potential fix for heritable diseases but it is extremely controversial because the changes would be passed down to future generations and could eventually affect the entire gene pool.

The MIT Technology Review warned "the technology is ethically charged".

The claims come ahead of a conference of world experts in Hong Kong this week, with He expected to speak on Wednesday and Thursday.

But there is as yet no independent verification of his claims, which have not been published in a peer-reviewed journal—an omission that the scientist's critics have seized on.

'Dangerous, irresponsible'

The research has been robustly criticised by Chinese scientists and institutions. The university where He works said he had been on unpaid leave since February and his research is a "serious violation of academic ethics and norms".

"This research work was carried out by Professor He Jiankui outside of the school," the Southern University of Science and Technology said in a statement Monday.

And a joint statement from a group of 100 scientists in China criticised the findings and called for better state legislation.

"It is a great blow to the global reputation and development of biomedical research in China," said the statement posted on social media platform Weibo.

"It is extremely unfair to the vast majority of Chinese scholars who are diligent in scientific research and innovation."

Other scientists all around the world were also critical, with some saying a YouTube video was an inadequate way of announcing scientific findings, and others warning that exposing healthy embryos and children to was irresponsible.

Professor Joyce Harper, professor in genetics and human embryology at London's UCL, said: "Today's report of genome editing human embryos for resistance to HIV is premature, dangerous and irresponsible."

History of fraud

The issue of editing human DNA is highly controversial, and only allowed in the US in laboratory research—although US scientists said last year that they had successfully edited the genetic code of piglets to remove dormant viral infections.

But this is not the first time Chinese researchers have experimented with human embryo technology, and last September scientists at Sun Yat-sen University used an adapted version of gene-editing to correct a disease-causing mutation in human embryos.

There is also a history of fraud within China's academic community—including a scandal last year that led to the withdrawal of 100 "compromised" academic papers.

He Jiankui did not immediately respond to a request for comment from AFP.

Neither was there any response from queries to the organisers of the Hong Kong conference, and it is not clear whether they were aware of He's work.

In a pre-recorded video on the conference's website, biologist and chair of the international summit David Baltimore said: "We have never done anything that will change the genes of the human race, and we have never done anything that will have effects that will go on through the generations."

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