NASA Ames reproduces the building blocks of life in laboratory

NASA Ames Reproduces the Building Blocks of Life in Laboratory
Left to right: Ames scientists Michel Nuevo, Christopher Materese and Scott Sandford reproduce uracil, cytosine, and thymine, three key components of our hereditary material, in the laboratory. Credit: NASA/ Dominic Hart

NASA scientists studying the origin of life have reproduced uracil, cytosine, and thymine, three key components of our hereditary material, in the laboratory. They discovered that an ice sample containing pyrimidine exposed to ultraviolet radiation under space-like conditions produces these essential ingredients of life.

Pyrimidine is a ring-shaped molecule made up of carbon and nitrogen and is the central structure for uracil, cytosine, and thymine, which are all three part of a genetic code found in ribonucleic (RNA) and deoxyribonucleic acids (DNA). RNA and DNA are central to protein synthesis, but also have many other roles.

"We have demonstrated for the first time that we can make uracil, cytosine, and thymine, all three components of RNA and DNA, non-biologically in a laboratory under conditions found in ," said Michel Nuevo, research scientist at NASA's Ames Research Center, Moffett Field, California. "We are showing that these laboratory processes, which simulate conditions in outer space, can make several fundamental building blocks used by living organisms on Earth."

An ice sample is deposited on a cold (approximately –440 degrees Fahrenheit) substrate in a chamber, where it is irradiated with high-energy ultraviolet (UV) photons from a hydrogen lamp. The bombarding photons break chemical bonds in the ices and break down the ice's molecules into fragments that then recombine to form new compounds, such as uracil, cytosine, and thymine.

NASA Ames scientists have been simulating the environments found in interstellar space and the outer Solar System for years. During this time, they have studied a class of carbon-rich compounds, called (PAHs), that have been identified in meteorites, and which are the most common carbon-rich compound observed in the universe. PAHs typically are structures based on several six-carbon rings that resemble fused hexagons, or a piece of chicken wire.

NASA Ames Reproduces the Building Blocks of Life in Laboratory
An ice sample is held at approximately -440 degrees Fahrenheit in a vacuum chamber, where it is irradiated with high energy UV photons from a hydrogen lamp. The bombarding photons break chemical bonds in the ice samples and result in the formation of new compounds, such as uracil. Credit: NASA/Dominic Hart

The molecule pyrimidine is found in meteorites, although scientists still do not know its origin. It may be similar to the carbon-rich PAHs, in that it may be produced in the final outbursts of dying, giant red stars, or formed in dense clouds of interstellar gas and dust.

"Molecules like pyrimidine have nitrogen atoms in their ring structures, which makes them somewhat wimpy. As a less stable molecule, it is more susceptible to destruction by radiation, compared to its counterparts that don't have nitrogen," said Scott Sandford, a space science researcher at Ames. "We wanted to test whether pyrimidine can survive in space, and whether it can undergo reactions that turn it into more complicated organic species, such as the nucleobases uracil, cytosine, and thymine."

In theory, the researchers thought that if molecules of pyrimidine could survive long enough to migrate into , they might be able to shield themselves from destructive radiation. Once in the clouds, most molecules freeze onto dust grains (much like moisture in your breath condenses on a cold window during winter).

These clouds are dense enough to screen out much of the surrounding outside radiation of space, thereby providing some protection to the molecules inside the clouds.

NASA Ames Reproduces the Building Blocks of Life in Laboratory
Pyrimidine is a ring-shaped molecule made up of carbon and nitrogen and is the central structure for uracil, cytosine, and thymine, which are found in RNA and DNA. Credit: NASA

Scientists tested their hypotheses in the Ames Astrochemistry Laboratory. During their experiment, they exposed the ice sample containing pyrimidine to ultraviolet radiation under space-like conditions, including a very high vacuum, extremely low temperatures (approximately –440 degrees Fahrenheit), and harsh radiation.

They found that when is frozen in ice mostly consisting of water, but also ammonia, methanol, or methane, it is much less vulnerable to destruction by radiation than it would be if it were in the gas phase in open space. Instead of being destroyed, many of the molecules took on new forms, such as the RNA/DNA components uracil, cytosine, and thymine, which are found in the genetic make-up of all living organisms on Earth.

NASA Ames Reproduces the Building Blocks of Life in Laboratory
The ring-shaped molecule pyrimidine is found in cytosine and thymine. Credit: NASA

"We are trying to address the mechanisms in space that are forming these molecules. Considering what we produced in the laboratory, the chemistry of ice exposed to may be an important linking step between what goes on in space and what fell to Earth early in its development," said Christopher Materese, another researcher at NASA Ames who has been working on these experiments.

"Nobody really understands how life got started on Earth. Our experiments suggest that once the Earth formed, many of the of life were likely present from the beginning. Since we are simulating universal astrophysical conditions, the same is likely wherever planets are formed," says Sandford.


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Scientists Reproduce a Building Block of Life in Laboratory

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Citation: NASA Ames reproduces the building blocks of life in laboratory (2015, March 5) retrieved 20 September 2019 from https://phys.org/news/2015-03-nasa-ames-blocks-life-laboratory.html
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Mar 05, 2015
NOW we're talkin'...

JVK
Mar 05, 2015
Provided by NASA

No publication or other source. Great picture and explanation of findings that cannot readily be found for evaluation.

Does anyone know how they could be linked to this published work?
The evolution of our local cosmic domain: effective causal limits http://mnras.oxfo...abstract

If not, should we assume there are no limits to the imaginations of researchers who think life evolved in deep space?

Mar 05, 2015
Provided by NASA

If not, should we assume there are no limits to the imaginations of researchers who think life evolved in deep space?


We found processes that generate necessary chemicals for our type of life happening very nearby. Don't worry I'm sure there's plenty of pheremones there too so you can sniff yourself up into a frenzy.

Also, there are an estimated 5 x 10^22 habitable planets in the universe, so if we are looking for the inhabited one, then yes, a broad imagination might help.


Mar 05, 2015
@ JVK-Skippy. How you are Cher? I'm real good, thanks.

No publication or other source. Great picture and explanation of findings that cannot readily be found for evaluation.

Does anyone know how they could be linked to this published work?
The evolution of our local cosmic domain: effective causal limits http://mnras.oxfo...abstract


I am not the scientist like you are not either so I have to give the Google-Skippy the credit for helping me help you with that.

Here is the paper this article is about. And some other ones too written by the same group of real scientist-Skippys who went to the sciences schools, unlike me and unlike you too.

http://www.pubfac...Materese

Don't thank me, thank Google-Skippy. He's usually pretty nice about answering questions from people who are not really scientists like me and like you too.

Mar 06, 2015
So, if the planet did get bombarded with a lot of asteroids with ice on them that had been floating around in space then the oceans would possibly have had quite a bit of this stuff floating around in it and on the land surface. Initial 'life' might have started up in a bunch of different spots on the planet and we are now descended from the most efficient and advanced version that managed to survive and grow.

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