Optimized application of high intensity focused ultrasound

February 10, 2015, Alpen-Adria-Universität Klagenfurt

The field of nonlinear acoustics is currently receiving a lot of attention, thanks to applications focused on the improvement of ultrasonic cleaning, ultrasonic welding, sonochemistry, or thermotherapy. Lithotripsy – the demolition of kidney stones based on the use of high intensity focused ultrasound – represents a further medical field of application.

A team at the Alpen-Adria-Universität including Rainer Brunnhuber, Vanja Nikolić and Barbara Kaltenbacher (Department of Mathematics) is currently working on the and simulation of models governing the propagation of sound in fluids. "These models are based on . The better our grasp of these equations, the more successfully one can avoid complications during the application of ultrasound technology", Rainer Brunnhuber explains.

To give an example, mathematical optimization methods can be used to enhance the shape of an acoustic lens in such a way that the acoustic pressure is focused precisely on the location of the kidney stone and the surrounding tissue retains as little damage as possible.

The mathematical analysis of underlying model equations represents an essential requirement for reliable and in-depth numerical simulation and optimization. The application-oriented comprehensive mathematical solution of the problem also involves the development of algorithms and their implementation on the basis of the knowledge gained. In the practical context this results in a reduction of the complication risks during the medical application of focused ultrasound.

The project "Mathematics of nonlinear acoustics: Analysis, numerics and optimization" is supported by the Austrian Science Fund (FWF).

Explore further: Using microbubbles to improve cancer therapy

More information: Rainer Brunnhuber and Barbara Kaltenbacher: "Well-posedness and asymptotic behavior of solutions for the Blackstock-Crighton-Westervelt equation," Discrete and Continuous Dynamical Systems 34 (2014), 4515-4535.

Rainer Brunnhuber, Barbara Kaltenbacher and Petronela Radu: "Relaxation of regularity for the Westervelt equation by nonlinear damping with application in acoustic-acoustic and elastic-acoustic coupling," Evolution Equations and Control Theory 3 (2014), 595-626.

Barbara Kaltenbacher, Vanja Nikolić and Mechthild Thalhammer: "Efficient time integration methods based on operator splitting and application to the Westervelt equation," IMA Journal of Numerical Analysis, DOI: 10.1093/imanum/dru029.

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