Scientists find cancer cell defense method

October 5, 2005

A Seoul, South Korea, research team says it's identified the defense mechanism used by cancer cells to fight therapeutic chemicals.

Team leader Kim Kun-hong of Yonsei University told the Korea Times the discovery that enzyme protein kinase CK2 makes cancer cells resistant to cancer-specific therapeutic chemicals, such as "Trail," is a step toward developing effective treatments for the disease.

Kim said the enzyme influences a protein called procaspase-2 to become phosphate, which keeps the cells from dying and makes them resistant to medication.

However, when Trail was injected in the cancer cells with certain chemical substances the cells became sensitive to Trail and entered the normal death-inducing process.

The researchers tested 31 types of cancer cells and found that by suppressing PKCK2, Trail successfully killed the cancer cells in all the 31 types, regardless of the developmental stage of the cancer cell, Kim told the Korea Times.

The research appears in the online edition of the journal of the European Molecular Biology Organization.

Copyright 2005 by United Press International

Explore further: New microscope captures detailed 3-D movies of cells deep within living systems

Related Stories

Potential therapy identified for aggressive breast cancer

January 25, 2018

The European Cancer Stem Cell Research Institute, based with Cardiff University, has repurposed a current cancer therapy, TRAIL, to find a new treatment for advanced cancers that are resistant to anti-hormone therapy.

Recommended for you

Climate change intensifies droughts in Europe

April 23, 2018

Global warming will exacerbate soil droughts in Europe—droughts will last longer, affect greater areas, and have an impact on more people. If the Earth warms by three degrees Celsius, extreme events could become the normal ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.