PLoS Computational Biology is a peer-reviewed computational biology journal established in 2005 and published by the nonprofit Public Library of Science in association with the International Society for Computational Biology. Its Editor in Chief is Philip Bourne. All articles are open access and licensed under the Creative Commons Attribution License. The journal is well-known beyond its core field for its Ten Simple Rules series of articles that capture the essence of selected aspects of research in computational biology or in science more generally, e.g. how to present a poster, how to collaborate, or how to edit Wikipedia. Due to their free licensing, files from PLoS Computational Biology can be reused in places other than the journal s website, e.g. to illustrate Wikipedia articles.
Partial mechanical unfolding may regulate protein function
A study carried out as a collaborative approach between University of Tampere, Finland, and Imperial College London has shown that mechanically regulated proteins talin and α-catenin have stable intermediates during mechanical ...
Apr 30, 2018
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Evolving our way to artificial intelligence
Researcher David Silver and colleagues designed a computer program capable of beating a top-level Go player – a marvelous technological feat and important threshold in the development of artificial intelligence, or AI. ...
Research showing why hierarchy exists will aid the development of artificial intelligence
New research explains why so many biological networks, including the human brain (a network of neurons), exhibit a hierarchical structure, and will improve attempts to create artificial intelligence. The study, published ...
New machine learning system can automatically identify shapes of red blood cells
Using a computational approach known as deep learning, scientists have developed a new system to classify the shapes of red blood cells in a patient's blood. The findings, published in PLOS Computational Biology, could potentially ...
Scientists create first viable mathematical model of a key anti-Salmonella defense system
Scientists have created the first validated mathematical model of an important cellular defense mechanism against the bacterium Salmonella, according to a new study in PLOS Computational Biology.
Mouth clicks used in human echolocation captured in unprecedented detail
Like some bats and marine mammals, people can develop expert echolocation skills, in which they produce a clicking sound with their mouths and listen to the reflected sound waves to "see" their surroundings. A new study published ...
Insect vector feeding recognized by machine learning
Scientists have used machine learning algorithms to teach computers to recognize the insect feeding patterns involved in pathogen transmission. The study, published in PLOS Computational Biology, also uncovers plant traits ...
Geometry, programmed death might have enabled evolution of multicellularity
Geometry and programmed cell death may have helped along the evolution of multicellular life, according to new research led by SFI Omidyar Fellow Eric Libby.
New insights into the evolution of cooperation in spatially structured populations
Researchers have analyzed a new mathematical model to investigate how a population's spatial structure affects the evolution of cooperation. Jorge Peña of the Max Planck Institute for Evolutionary Biology in Plön, Germany, ...
New algorithm tracks neurons in bendy brain of freely crawling worm
Scientists at Princeton University have developed a new algorithm to track neurons in the brain of the worm Caenorhabditis elegans while it crawls. The algorithm, presented in PLOS Computational Biology by Jeffrey Nguyen ...
