How time affects the fate of stem cells

How do temporal variations in protein concentrations affect biology? It's a question that biologists have only recently begun to address, and the findings are increasingly showing that random temporal changes in the amount ...

Machine learning sheds light on the biology of toxin exposure

Exposure to potentially harmful chemicals is a reality of life. Our ancestors, faced with naturally occurring toxins, evolved mechanisms to detoxify and expel damaging substances. In the modern world, our bodies regularly ...

Revealing the role of the mysterious small proteins

The human genome contains an estimated 20,000 genes coding for proteins. The proteins are the body's "workers," tasked with performing specific functions that are key to survival. Despite their importance, there is a type ...

New molecular tool identifies sugar-protein attachments

Researchers at Johns Hopkins Medicine have developed a new molecular tool they call EXoO, which decodes where on proteins specific sugars are attached—a possible modification due to disease. The study, published in issue ...

The protein with the starting gun

Whether dormant bacteria begin to reproduce is no accidence. Rather, they are simply waiting for a clear signal from a single protein in the cell interior. ETH researchers have now deciphered the molecular mechanisms behind ...

Melting bacteria to decipher antibiotic resistance

With antibiotic resistance spreading worldwide, there is a strong need for new technologies to study bacteria. EMBL researchers have adapted an existing technique to study the melting behaviour of proteins so that it can ...

Dynamic modeling helps predict the behaviors of gut microbes

The human gut is teeming with microbes, each interacting with one another in a mind-boggling network of positive and negative exchanges. Some produce substances that serve as food for other microbes, while others produce ...

Measuring molecular interactions

ETH Zurich researchers have used a new approach to discover previously unknown interactions between proteins and small metabolic molecules in bacterial cells. The technique can also be used to test the effect of medications.

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