Cyclic hypervalent bromines act as aryne precursors

Diaryl λ3-bromanes are a rare and generally unresearched class of compounds. A mild and efficient protocol now delivers a broad palette of these interesting building blocks for organic synthesis. As a French research team ...

Mechanochemical peptide bond formation behind the origins of life

The presence of amino acids on the prebiotic Earth is widely accepted, either coming from endogenous chemical processes or being delivered by extraterrestrial material. On the other hand, plausibly prebiotic pathways to peptides ...

Bicyclic protein mimetics inhibit the oncogene β-catenin

The inhibition of pathological protein–protein interactions is a promising approach for treating a large number of diseases, including many forms of cancer. A team of researchers has now developed a bicyclic peptide that ...

Cell cytoskeleton as target for new active agents

Through a unique combination of computer simulations and laboratory experiments, researchers at the Paul Scherrer Institute (PSI) have discovered new binding sites for active agents—against cancer, for example—on a vital ...

Stabilization of the borafluorene anion with carbenes

The incorporation of boron into polycyclic aromatic hydrocarbon systems leads to interesting chromophoric and fluorescing materials for optoelectronics, including organic light-emitting diodes (OLEDS) and field-effect transistors, ...

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