Bicyclic protein mimetics inhibit the oncogene β-catenin

The inhibition of pathological protein–protein interactions is a promising approach for treating a large number of diseases, including many forms of cancer. A team of researchers has now developed a bicyclic peptide that ...

Cell cytoskeleton as target for new active agents

Through a unique combination of computer simulations and laboratory experiments, researchers at the Paul Scherrer Institute (PSI) have discovered new binding sites for active agents—against cancer, for example—on a vital ...

Stabilization of the borafluorene anion with carbenes

The incorporation of boron into polycyclic aromatic hydrocarbon systems leads to interesting chromophoric and fluorescing materials for optoelectronics, including organic light-emitting diodes (OLEDS) and field-effect transistors, ...

Release of drugs from a supramolecular cage

How can a highly effective drug be transported to the precise location in the body where it is needed? In the journal Angewandte Chemie, chemists at Heinrich Heine University Düsseldorf (HHU) together with colleagues in ...

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