Page 18: Research news on Self-assembly

Self-assembly as a research area investigates the spontaneous organization of components into ordered structures driven by local interactions and thermodynamic or kinetic principles, without direct external manipulation of each element. It encompasses molecular, nanoscale, and mesoscale systems where noncovalent forces (e.g., van der Waals, electrostatic, hydrophobic, hydrogen bonding) or specific binding interactions encode structural information. Research focuses on understanding design rules, energy landscapes, and defect formation, as well as developing programmable systems (e.g., DNA origami, block copolymers, colloidal crystals) for applications in materials science, nanotechnology, and biotechnology, often linking equilibrium self-assembly with nonequilibrium and hierarchical assembly processes.

Building a DNA nanoparticle to be both carrier and medicine

Scientists have been making nanoparticles out of DNA strands for two decades, manipulating the bonds that maintain DNA's double-helical shape to sculpt self-assembling structures that could someday have jaw-dropping medical ...

On-demand conformation of an artificial cytoskeleton

Peptide nanotubes are tubular-shaped structures formed by the controlled stacking of cyclic peptide components. These hollow biomaterials show inner and outer faces, allowing control over their properties.

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