Regeneration is a biological process by which organisms restore or replace lost or damaged tissues, organs, or body parts through controlled cell proliferation, differentiation, and patterning. It involves activation of resident stem or progenitor cells, dedifferentiation of mature cells in some taxa, and re-establishment of appropriate positional information via morphogen gradients and signaling pathways such as Wnt, FGF, BMP, and Notch. Regeneration can be epimorphic, with blastema formation and large-scale pattern reconstruction, or morphallactic, involving extensive tissue remodeling. Its extent and fidelity are species- and tissue-specific, constrained by genetic programs, immune responses, and age-dependent changes in cellular plasticity.
Extracellular vesicles (EVs) are tiny biological bubbles that carry nucleic acids and proteins between cells, playing an essential role in tissue repair, neuroprotection and immune health. By isolating the surface proteins ...
Bio & Medicine
Feb 23, 2026
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52
A new study has found that L1td1, a protein evolutionarily co-opted from the Long interspersed nuclear element 1 (LINE1) retrotransposon, functions as a critical "gatekeeper" restricting pluripotent stem cells (PSCs) from ...
Cell & Microbiology
Feb 10, 2026
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14
Muscles make up nearly 40% of the human body and power every move we make, from a child's first steps to recovery after injury. For some, however, muscle development goes awry, leading to weakness, delayed motor milestones ...
Molecular & Computational biology
Feb 5, 2026
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83
Some mammals hibernate to survive in winter, but the Eurasian common shrew (Sorex araneus) employs Dehnel's phenomenon to get through it. This is a metabolic process that enables shrews to conserve energy by shrinking their ...
Plants & Animals
Feb 3, 2026
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19
Aging muscles heal more slowly after injury—a frustrating reality familiar to many older adults. A UCLA study conducted in mice reveals an unexpected cause: Stem cells in aged muscle accumulate higher levels of a protein ...
Cell & Microbiology
Jan 31, 2026
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664
Skeletal muscle stem cells in hibernating Syrian hamsters preserve their ability to function by suppressing their activation during the hibernation period, a research team led by Hiroshima University has shown. This insight ...
Cell & Microbiology
Jan 26, 2026
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73
The kidney's proximal tubule reabsorbs water, glucose, ions and other small molecules from the urine and thus maintains the body's supply of these essential constituents. The tubule can be easily damaged by ischemia, or poor ...
Cell & Microbiology
Jan 19, 2026
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557
Researchers at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, in collaboration with Osaka University and the National Institutes for Quantum Science and Technology, have uncovered a previously unknown ...
Bio & Medicine
Jan 13, 2026
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28
As we age, we don't recover from injury or illness like we did when we were young. But new research from UCSF has found gene regulators—proteins that turn genes on and off—that could restore the aging body's ability to self-repair.
Cell & Microbiology
Jan 12, 2026
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82
In Finland, farmers who have transitioned to regenerative agriculture are forming a regenerative professional partnership with nature in their decision-making, a new study from the University of Eastern Finland shows.
Ecology
Jan 7, 2026
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