Research news on Regeneration

Regeneration is a biological process by which organisms restore or replace lost or damaged tissues, organs, or body parts through controlled cell proliferation, differentiation, and patterning. It involves activation of resident stem or progenitor cells, dedifferentiation of mature cells in some taxa, and re-establishment of appropriate positional information via morphogen gradients and signaling pathways such as Wnt, FGF, BMP, and Notch. Regeneration can be epimorphic, with blastema formation and large-scale pattern reconstruction, or morphallactic, involving extensive tissue remodeling. Its extent and fidelity are species- and tissue-specific, constrained by genetic programs, immune responses, and age-dependent changes in cellular plasticity.

Using menstrual blood-derived particles to treat osteoarthritis

New research by an interdisciplinary team in Lithuania has revealed a promising and unconventional approach to cartilage regeneration. Using extracellular vesicles derived from menstrual blood stromal cells, the researchers ...

Split shift: A surprising twist in the biology of aging

A new Yale study of flatworms, a species with the unique ability to regenerate, reveals that disruptions in the body's internal map of cellular organization may play a part in age-related decline.

Cell death in photoreceptor cells is reversible, study finds

Photoreceptors are specialized cells in the eye that convert light energy into neural signals. Several diseases that cause irreversible vision loss, including age-related macular degeneration, retinitis pigmentosa and retinal ...

How flatworms keep their regeneration powers on track

Scientists have discovered a key biological safeguard that helps one of nature's most impressive regenerators, the planarian flatworm, correctly rebuild its organs. The new research, published in Nature Communications, illuminates ...

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