Organelle biogenesis is the biological process by which cells establish, maintain, and propagate their membrane-bound compartments, including their specific protein and lipid compositions, morphology, and copy number. It involves de novo formation from precursor membranes (e.g., ER-derived peroxisomes), growth and division of pre-existing organelles (e.g., mitochondria, chloroplasts), and tightly regulated trafficking of proteins and lipids via targeted import, vesicular transport, and membrane remodeling. Organelle biogenesis is coordinated with the cell cycle, metabolic state, and signaling pathways, relying on dedicated machineries such as translocases, coat proteins, small GTPases, and cytoskeletal elements to ensure fidelity of organelle identity and function across cell generations.
Transverse tubules (T-tubules) play a significant role in muscle contraction. However, the underlying mechanism of their formation is yet to be elucidated. In a recent study, a research team from Japan used a Drosophila model ...
Cell & Microbiology
Jan 7, 2026
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A previously unknown type of DNA damage in the mitochondria, the tiny power plants inside our cells, could shed light on how our bodies sense and respond to stress. The findings of the UC Riverside-led study are published ...
Cell & Microbiology
Nov 19, 2025
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203
University of Liverpool and Newcastle researchers have uncovered how bacterial organelles assemble, opening new routes for bioengineering and climate innovation.
Bio & Medicine
Nov 10, 2025
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72
A research team led by Professor Wang Peng from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences, together with international researchers, has successfully engineered liquid-liquid phase separation ...
Cell & Microbiology
Nov 5, 2025
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In many cells of the human body, hair-like protrusions known as cilia act as antennae, allowing cells to receive signals from their environment and other cells. As cells grow and divide, each cilium must first form on the ...
Cell & Microbiology
Oct 29, 2025
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34
Peroxisomes are essential cell organelles that play a vital role in lipid metabolism and cellular detoxification. To perform these functions, numerous enzymes must be correctly transported into the organelles.
Cell & Microbiology
Oct 29, 2025
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Ribosomes are the cell's protein factories, which read the genetic code and assemble the proteins that every organism needs to live. But as far as how ribosomes themselves were formed, tantalizingly little was known.
Cell & Microbiology
Oct 29, 2025
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109
A team at McGill University studying ferroptosis, a form of cell death, have discovered that the process begins deep inside the cell, a finding that could lead to new treatments for cancer and neurodegenerative diseases.
Cell & Microbiology
Oct 22, 2025
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41
A new study from The University of Texas at Arlington has revealed how cells control their mitochondria—the "energy producers" of cells—during the process of cell death. The discovery sheds light on how the body manages this ...
Cell & Microbiology
Oct 16, 2025
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49
Nearly every cell in your body depends on mitochondria to survive and function properly. Mitochondria provide 90% of our bodies' energy, but less well-known are their roles in cellular signaling and in eliminating defective ...
Cell & Microbiology
Sep 26, 2025
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