Organelle biogenesis is the biological process by which cells establish, maintain, and propagate their membrane-bound compartments, including their specific protein and lipid compositions, morphology, and copy number. It involves de novo formation from precursor membranes (e.g., ER-derived peroxisomes), growth and division of pre-existing organelles (e.g., mitochondria, chloroplasts), and tightly regulated trafficking of proteins and lipids via targeted import, vesicular transport, and membrane remodeling. Organelle biogenesis is coordinated with the cell cycle, metabolic state, and signaling pathways, relying on dedicated machineries such as translocases, coat proteins, small GTPases, and cytoskeletal elements to ensure fidelity of organelle identity and function across cell generations.
A new study conducted by researchers from the University of Potsdam and the University of Cologne has deciphered the step-by-step assembly of the eukaryotic proteasome. Eukaryotes are organisms whose cells have a clearly ...
Cell & Microbiology
Mar 24, 2026
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After a heart attack, the heart struggles to recoup and maintain energy. One-third of patients develop heart failure as a result—a condition that impacts 6.8 million Americans and carries a high lifetime risk, with 1 in 4 ...
Cell & Microbiology
Mar 9, 2026
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45
A new study has uncovered a hidden step that helps the deadliest malaria parasite survive and multiply inside the human body. Researchers studying Plasmodium falciparum found that the parasite relies on a brief but essential ...
Cell & Microbiology
Feb 4, 2026
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A new study shows how one of the cell's most important energy-producing machines is built. Researchers at Karolinska Institutet have mapped late steps in the formation of the human respirasome, a large protein assembly that ...
Cell & Microbiology
Jan 19, 2026
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763
Transverse tubules (T-tubules) play a significant role in muscle contraction. However, the underlying mechanism of their formation is yet to be elucidated. In a recent study, a research team from Japan used a Drosophila model ...
Cell & Microbiology
Jan 7, 2026
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A previously unknown type of DNA damage in the mitochondria, the tiny power plants inside our cells, could shed light on how our bodies sense and respond to stress. The findings of the UC Riverside-led study are published ...
Cell & Microbiology
Nov 19, 2025
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201
University of Liverpool and Newcastle researchers have uncovered how bacterial organelles assemble, opening new routes for bioengineering and climate innovation.
Bio & Medicine
Nov 10, 2025
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72
A research team led by Professor Wang Peng from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences, together with international researchers, has successfully engineered liquid-liquid phase separation ...
Cell & Microbiology
Nov 5, 2025
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23
In many cells of the human body, hair-like protrusions known as cilia act as antennae, allowing cells to receive signals from their environment and other cells. As cells grow and divide, each cilium must first form on the ...
Cell & Microbiology
Oct 29, 2025
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34
Peroxisomes are essential cell organelles that play a vital role in lipid metabolism and cellular detoxification. To perform these functions, numerous enzymes must be correctly transported into the organelles.
Cell & Microbiology
Oct 29, 2025
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