Immune evasion is a biological process by which pathogens, tumor cells, or other aberrant cells avoid detection, recognition, or elimination by the host immune system, thereby promoting persistence and proliferation. Mechanisms include antigenic variation, downregulation or loss of major histocompatibility complex (MHC) molecules, expression of immune checkpoint ligands (e.g., PD-L1), secretion of immunosuppressive cytokines, induction of regulatory T cells or myeloid-derived suppressor cells, and shielding of antigens within biofilms or physical barriers. This process critically influences infection chronicity, tumor progression, vaccine efficacy, and the outcome of host–pathogen or host–tumor coevolution.
As they grow, solid tumors surround themselves with a thick, hard-to-penetrate wall of molecular defenses. Getting drugs past that barricade is notoriously difficult. Now, scientists at UT Southwestern have developed nanoparticles ...
Bio & Medicine
Jun 23, 2022
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Scientists at the University of Michigan Rogel Cancer Center were optimistic when they identified a small molecule that blocked a key pathway in brain tumors. But there was a problem: How to get the inhibitor through the ...
Bio & Medicine
May 26, 2022
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Researchers at Karolinska Institutet in Sweden have developed a novel strategy for identifying potent miniature antibodies, so-called nanobodies, against emerging SARS-CoV-2 variants. The approach led to the discovery of ...
Bio & Medicine
Mar 25, 2022
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A new approach to send 'friendly' nano-particles into a patient's blood stream has shown promising results by modifying the surface of these potential drug, vaccine or cancer treatment delivery objects to encourage the best ...
Bio & Medicine
Mar 10, 2022
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One of the most promising avenues in treating cancer is to restore our immune system's ability to recognize and attack cancerous cells. A team of University of Chicago chemists and biologists developed a tiny device that ...
Bio & Medicine
Mar 3, 2022
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Researchers at Penn Medicine have discovered a new, more effective method of preventing the body's own proteins from treating nanomedicines like foreign invaders, by covering the nanoparticles with a coating to suppress the ...
Bio & Medicine
Jan 11, 2022
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Researchers at Wake Forest School of Medicine have discovered that a nanoparticle therapeutic enhances cancer immunotherapy and is a possible new approach in treating malignant pleural effusion (MPE). MPE is the accumulation ...
Bio & Medicine
Dec 16, 2021
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140
To grow and spread, cancer cells must evade the immune system. Investigators from Brigham and Women's Hospital and MIT used the power of nanotechnology to discover a new way that cancer can disarm its would-be cellular attackers ...
Bio & Medicine
Nov 18, 2021
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299
Cell membrane coated biomimetic nanoparticles (NPs) have been widely studied in nanomedicine because of their unique properties such as immune escaping, long blood circulation, specific molecular recognition and efficient ...
Bio & Medicine
Sep 30, 2021
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Cancer immunotherapy such as immune checkpoint blockade (ICB) is a revolutionary treatment against tumors by re-enforcing immune surveillance and even inducing long-term disease control.
Bio & Medicine
Sep 29, 2021
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