Genetically engineered organisms (GEOs) are biological entities—prokaryotic or eukaryotic—whose genomes have been deliberately modified using recombinant DNA technologies, genome editing tools (e.g., CRISPR-Cas systems, TALENs, ZFNs), or transgenic methods to introduce, delete, or alter specific genetic sequences. This topic encompasses the design, construction, and characterization of modified genomes; vector systems and delivery methods; control of gene expression; and assessment of phenotypic consequences, stability, and off-target effects. It also includes applications in basic research, biotechnology, agriculture, biopharmaceutical production, and synthetic biology, as well as associated biosafety, containment, and regulatory frameworks governing experimental and environmental use.
We are continually in an evolutionary arms race with bacteria. As we develop new antibiotics, they develop resistance, and so it goes on until some of our treatments no longer work. Superbugs and antimicrobial resistance ...
In a demonstration that could help pave the way for gene therapies with fewer side effects, several human cell types have been genetically modified with protein nanoparticles designed at University of Michigan Engineering ...
Bio & Medicine
Mar 30, 2026
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106
A multi-institutional team of scientists, co-led by Northwestern University, has taken a crucial step toward implantable "living pharmacies"—tiny devices containing engineered cells that continuously produce medicines inside ...
Cell & Microbiology
Mar 27, 2026
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Cornell scientists have engineered E. coli to act as a sensitive biosensor for monitoring environmental arsenic, a toxic pollutant most notably found in rice paddies in Southeast Asia. Their new study provides a proof of ...
Cell & Microbiology
Mar 23, 2026
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9
Rice is a vital crop that feeds more than half of the world's population. In the wild, many rice species are perennials that live for several years, but the varieties we eat today are typically annuals that must be replanted ...
Imagine that plants could tell us exactly when they're stressed, infected, or being eaten by insects, by lighting up. A new study led by Dr. Karen Sarkisyan, Head of the Synthetic Biology group at the MRC Laboratory of Medical ...
Biotechnology
Mar 19, 2026
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51
Demand for odor detection is growing in diverse fields such as food security, medical diagnostics, and environmental monitoring, but current technologies face limitations. Living cells with olfactory receptors can serve as ...
Cell & Microbiology
Mar 17, 2026
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9
An international team of researchers has achieved a breakthrough in the production of doxorubicin, a vital chemotherapy agent. The study identifies and resolves molecular "bottlenecks" that have limited the natural production ...
Biotechnology
Mar 13, 2026
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118
An interdisciplinary research team from two working groups at the Center for Synthetic Biology at TU Darmstadt has developed the first RNA-based genetic switch that precisely replicates the logical behavior of a NAND gate, ...
Biotechnology
Mar 11, 2026
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56
An international team of researchers has modified a probiotic yeast to make it safer for use by immunocompromised people, older adults and infants. Testing in an animal model found that the modified yeast is less likely to ...
Cell & Microbiology
Mar 9, 2026
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