DNA sequencing is a set of laboratory methods for determining the precise linear order of nucleotides (A, C, G, T) in a DNA molecule. Core methodological classes include Sanger sequencing, which uses chain-terminating dideoxynucleotides and capillary electrophoresis for high-fidelity, low-throughput analysis, and next-generation sequencing (NGS) platforms, which employ massively parallel sequencing-by-synthesis, sequencing-by-ligation, or nanopore-based readout for high-throughput, genome-scale applications. These methods entail library preparation, clonal or single-molecule amplification (except in true single-molecule approaches), signal detection, and computational base-calling, followed by quality control and downstream bioinformatic analysis.
A new genomic resource from the Texas A&M AgriLife Research plant genomics team is providing a powerful new foundation for faster, more precise turfgrass genetics and breeding. The team discovered a breakthrough genome that ...
Biotechnology
Aug 7, 2026
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A new study by ancient DNA researchers at the University of California, Santa Cruz, used paleogenomics to create a genetic roadmap to help guide the restoration of another iconic species once on the brink of extinction: the ...
Plants & Animals
Aug 6, 2026
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The zebra finch is one of the best-studied songbirds and a model for understanding the biology and neuroscience of vocal learning. Now, researchers have produced the first complete genome assembly of the species, revealing ...
Plants & Animals
Aug 6, 2026
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72
Heart-healthy oats are finding their way into a wider variety of products and recipes as consumer demand grows. Although oats are grown on far fewer acres than other U.S. crops, farmers are able to keep up with demand through ...
Molecular & Computational biology
Aug 6, 2026
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7
From routine surgeries to cancer treatment, modern medicine depends on drugs that can fight infections caused by microbes such as bacteria, viruses, fungi and parasites. But some microbes are becoming resistant to the drugs ...
Cell & Microbiology
Aug 5, 2026
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140
How readily a cell divides and how well it survives are fundamental to life, shaping everything from organ size to the body's ability to withstand disease. That combination, known as cell fitness, isn't the same for everyone. ...
Cell & Microbiology
Aug 4, 2026
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14
Researchers sequenced the genomes of three medaka, or Japanese rice fish, a common model organism used in biological research, nearly 10 and 20 years ago. While sequencing the genomes was relatively straightforward, assembling ...
Plants & Animals
Aug 4, 2026
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7
Analyzing ancient DNA from more than 500 mammoth bones, an international team of researchers found that Ice Age humans selectively targeted female woolly mammoths. The results of the study, published in Current Biology, show ...
Paleontology & Fossils
Jul 30, 2026
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90
The arms race between bacteria and antibiotics is nothing new—antimicrobial resistance has been an emerging issue in human and animal health for a long time. But in a new review published in JAC-Antimicrobial Resistance, ...
Molecular & Computational biology
Jul 28, 2026
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9
Researchers have developed a DNA vacuum that can suck genetic traces from animals out of the air and reveal which animals live in an area. In two new studies, the researchers collected air samples in three natural areas in ...
Ecology
Jul 26, 2026
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