DNA sequencing is a set of laboratory methods for determining the precise linear order of nucleotides (A, C, G, T) in a DNA molecule. Core methodological classes include Sanger sequencing, which uses chain-terminating dideoxynucleotides and capillary electrophoresis for high-fidelity, low-throughput analysis, and next-generation sequencing (NGS) platforms, which employ massively parallel sequencing-by-synthesis, sequencing-by-ligation, or nanopore-based readout for high-throughput, genome-scale applications. These methods entail library preparation, clonal or single-molecule amplification (except in true single-molecule approaches), signal detection, and computational base-calling, followed by quality control and downstream bioinformatic analysis.
Modern biology research can now generate valuable data on an unprecedented scale. But there is one major obstacle: making sense of these complex high-dimensional datasets. A team at the University of Basel, Switzerland, has ...
Biotechnology
Aug 21, 2026
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100 million years ago, long before human intervention, ancestors of grasses, including wheat, rice and maize, developed "bypasses" in chemical pathways used to create two critical compounds: lignin and starch. These more ...
Plants & Animals
Aug 20, 2026
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Rye is not only a hardy and high-yielding crop, but also possesses a valuable gene pool for wheat breeding. An international research team led by the IPK Leibniz Institute has significantly improved the foundations for research ...
Molecular & Computational biology
Aug 19, 2026
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Scientists studying one of nature's greatest reproductive innovations have discovered how some lizards evolved from laying eggs to giving birth to live young. The new research is the first to reveal the evolutionary process ...
Plants & Animals
Aug 19, 2026
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Humans love dogs, but petting them can leave some people sneezing and wheezing. About 15% of the world's population lives with a dog allergy, which can increase the risk of hay fever and asthma. The main culprit is Can f ...
Like a delivery driver navigating crowded city streets, a gene-therapy-toting lipid nanoparticle faces a gauntlet of potential detours on its journey toward a cell's nucleus. First, there's entering the cell's plasma membrane; ...
Cell & Microbiology
Aug 13, 2026
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158
Ancient trees—those that are remarkably old for their species—are declining worldwide, raising concerns about the loss of the ecological and evolutionary history they represent. Their exceptional longevity has long encouraged ...
Plants & Animals
Aug 12, 2026
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They may look like any ordinary species of flies buzzing around on any given day, but the New World screwworm is quite extraordinary. Screwworm flies are highly destructive parasitic flies that feed on the tissue of warm-blooded ...
Ecology
Aug 12, 2026
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6
A centromere is a specific region on a chromosome that ensures that, when a cell divides, the chromosome separates accurately so each new cell receives the correct amount of genetic material. Despite their essential role, ...
Scientists at the Department of Energy's Oak Ridge National Laboratory have created a platform that pinpoints genetic triggers that turn microbes into efficient factories for new chemicals and materials. The method enables ...
Cell & Microbiology
Aug 7, 2026
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