DNA sequencing is a set of laboratory methods for determining the precise linear order of nucleotides (A, C, G, T) in a DNA molecule. Core methodological classes include Sanger sequencing, which uses chain-terminating dideoxynucleotides and capillary electrophoresis for high-fidelity, low-throughput analysis, and next-generation sequencing (NGS) platforms, which employ massively parallel sequencing-by-synthesis, sequencing-by-ligation, or nanopore-based readout for high-throughput, genome-scale applications. These methods entail library preparation, clonal or single-molecule amplification (except in true single-molecule approaches), signal detection, and computational base-calling, followed by quality control and downstream bioinformatic analysis.
An international team of scientists has decoded some of the most stubborn, overlooked regions of the human genome using complete sequences from 65 individuals across diverse ancestries.
Biotechnology
Jul 23, 2025
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A world-first tool is tracking Australia's progress in sequencing the full genomes—or genetic blueprints—of the country's 250,000-plus known and catalogued species.
Molecular & Computational biology
Jul 23, 2025
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17
Since the Human Genome Project first produced the genetic instructions for a human being by sequencing DNA 22 years ago, scientists have been focused on roughly 2% of the genome-producing proteins.
Molecular & Computational biology
Jul 17, 2025
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23
A team that includes Rutgers University-New Brunswick scientists has unlocked some of the secrets of corn DNA, revealing how specific sections of genetic material control vital traits such as plant architecture and pest resistance.
Molecular & Computational biology
Jul 15, 2025
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38
Scientists have sequenced the complete genome of a roundworm used extensively in biological research, opening a new pathway for synthetic biologists to build and test genetic changes in a multicellular animal species. The ...
Molecular & Computational biology
Jul 15, 2025
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20
Creating genomes from DNA is hugely important for managing threatened species—understanding their past and how they have adapted to their environment helps conservationists protect them.
Plants & Animals
Jul 8, 2025
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29
Imagine that you want to know the plot of a movie, but you only have access to either the visuals or the sound. With visuals alone, you'll miss all the dialog. With sound alone, you will miss the action. Understanding our ...
Biotechnology
Jul 1, 2025
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28
Using whole genome sequencing and cutting‐edge analyses, researchers at Stockholm University have uncovered the surprising evolutionary history of the Norwegian lemming (Lemmus lemmus), revealing it to be one of the most ...
Plants & Animals
Jun 30, 2025
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81
Effective and noninvasive whale and biodiversity monitoring is now possible with the help of citizen scientists, opening up new opportunities for marine conservation. Water samples collected during whale-watching tours contain ...
Ecology
Jun 27, 2025
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41
Antibiotics are one of the greatest triumphs in the history of medical science—but these lifesaving tools have a dark side. Their persistent use can produce "superbugs"—drug-resistant microbes that pose a danger to humans, ...
Biotechnology
Jun 27, 2025
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