DNA sequencing is a set of laboratory methods for determining the precise linear order of nucleotides (A, C, G, T) in a DNA molecule. Core methodological classes include Sanger sequencing, which uses chain-terminating dideoxynucleotides and capillary electrophoresis for high-fidelity, low-throughput analysis, and next-generation sequencing (NGS) platforms, which employ massively parallel sequencing-by-synthesis, sequencing-by-ligation, or nanopore-based readout for high-throughput, genome-scale applications. These methods entail library preparation, clonal or single-molecule amplification (except in true single-molecule approaches), signal detection, and computational base-calling, followed by quality control and downstream bioinformatic analysis.
In an advance that could one day lead to new treatments for neurodegenerative diseases, Meredith Jackrel, an associate professor of chemistry in Arts & Sciences at Washington University in St. Louis, and her team have developed ...
Biotechnology
Jun 13, 2026
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Researchers at the Center for Crop and Disease Management (CCDM) have developed a new system that combines spore trapping with advanced DNA sequencing to confirm fungicide resistance from air samples containing airborne spores.
Biotechnology
Jun 10, 2026
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The deep sea is a unique "evolutionary engine," with one of the richest and most unexplored sources of genetic diversity on Earth, according to a major new study that assessed its potential to transform biotechnology and ...
Evolution
Jun 10, 2026
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Sloths are the slowest mammals on the planet, but living in dense jungles has made them notoriously difficult to study. For the first time, scientists have now sequenced and analyzed the two-toed sloth genome and revealed ...
Evolution
Jun 9, 2026
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Ground squirrel droppings, preserved for millennia in the Yukon's deep permafrost, have yielded an enormous amount of environmental DNA from dozens of species of plants, insects, microbes and large mammals, offering detailed ...
Evolution
Jun 9, 2026
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A new technology allows scientists to map, in single cells, the DNA binding sites of transcription factors and other regulatory proteins that control gene activity, according to a study led by investigators at Weill Cornell ...
Cell & Microbiology
Jun 4, 2026
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9
The first comprehensive map of nearly the entire Greenland shark genome is beginning to reveal some of the genetic clues behind its incredibly long life. The work could one day help scientists develop new cures and treatments ...
Their fur might feel the same, but a mink in the Everglades is not the same as a mink from northern Florida, researchers from the University of Connecticut and Central Connecticut State University report in the April 20 issue ...
Plants & Animals
May 28, 2026
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Researchers from Sciensano, partner of the DARWIN project, have published a new paper in npj Science of Food addressing one of the key scientific and regulatory challenges linked to genome-edited (GE) organisms, their reliable ...
Biotechnology
May 27, 2026
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In evolutionary biology, all life on Earth is theoretically part of a single phylogenetic tree, indicating common ancestry. This model suggests that every living organism can be traced back to a distant common ancestor. However, ...
Molecular & Computational biology
May 26, 2026
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