DNA sequencing is a set of laboratory methods for determining the precise linear order of nucleotides (A, C, G, T) in a DNA molecule. Core methodological classes include Sanger sequencing, which uses chain-terminating dideoxynucleotides and capillary electrophoresis for high-fidelity, low-throughput analysis, and next-generation sequencing (NGS) platforms, which employ massively parallel sequencing-by-synthesis, sequencing-by-ligation, or nanopore-based readout for high-throughput, genome-scale applications. These methods entail library preparation, clonal or single-molecule amplification (except in true single-molecule approaches), signal detection, and computational base-calling, followed by quality control and downstream bioinformatic analysis.
Genome editing lets scientists rewrite DNA, the instruction manual inside every living cell, with a precision that was unthinkable a generation ago. Technologies such as CRISPR have made this almost routine, and its uses ...
Biotechnology
Jun 24, 2026
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One of the world's most significant collections of plant specimens is under threat from the ongoing war in Ukraine, prompting an international call for urgent digitization and global collaboration to preserve an irreplaceable ...
Plants & Animals
Jun 24, 2026
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Researchers have identified "DNA switches" that become active as honeybee larvae grow into worker bees, offering new insight into the development of these important pollinators and the ecosystems they support.
Ecology
Jun 23, 2026
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Spoorti Gandhadmath carefully placed 3.5-inch (8.9-centimeter) pots on a shelf in a growth chamber. Within seven days of sowing, newly sprouted leaves had fully emerged from each of the carefully selected seeds, representing ...
Molecular & Computational biology
Jun 22, 2026
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Peanuts are an important staple crop for many people around the world. As well as being delicious as smooth or crunchy peanut butter, their seeds are high in healthy fats and protein and can be pressed into oil.
Molecular & Computational biology
Jun 17, 2026
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Genes aren't just transferred from parents to their offspring. Nature has found other ways to pass on genetic information, even between different species. And a new study, published in the journal Proceedings of the National ...
A new study led by Marco Fumasoni, principal investigator at Fundação GIMM, shows that evolution can substantially reduce cell size without significantly compromising cells' ability to grow. The work, carried out in yeast ...
Evolution
Jun 17, 2026
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An interdisciplinary team of Rice University researchers has uncovered previously unknown relationships between bacteriophages—viruses that infect bacteria—and their bacterial hosts, offering a powerful new tool for next-generation ...
Cell & Microbiology
Jun 16, 2026
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Genome sequencing has revealed insights into how current-day residents of the Faroe Islands can trace their ancestry to a North Atlantic founder population and how evolutionary forces have shaped their genomes since. The ...
Evolution
Jun 16, 2026
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In an advance that could one day lead to new treatments for neurodegenerative diseases, Meredith Jackrel, an associate professor of chemistry in Arts & Sciences at Washington University in St. Louis, and her team have developed ...
Biotechnology
Jun 13, 2026
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