Biomolecular and subcellular processes constitute a research area focused on the molecular mechanisms and dynamic interactions that underlie cellular function, organization, and regulation at nanometer to micrometer scales. It encompasses studies of protein folding and trafficking, nucleic acid structure and metabolism, signal transduction, membrane transport, organelle biogenesis, cytoskeletal dynamics, and macromolecular complex assembly. This field integrates biochemical, biophysical, structural, imaging, and computational approaches to quantify reaction kinetics, spatial organization, and emergent behaviors within cells, aiming to relate molecular-level events to higher-order cellular phenotypes, robustness, and dysfunction in contexts such as development, stress responses, and disease.
How proteins in our cells attain their correct three-dimensional structure is crucial to their function—and to our health. Errors in this process can lead to serious diseases. Researchers at the Center for Medical Biotechnology ...
Cell & Microbiology
Jul 21, 2025
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19
An international team led by Einstein Professor Cecilia Clementi in the Department of Physics at Freie Universität Berlin has introduced CGSchNet, a machine-learned coarse-grained (CG) model that can accurately and efficiently ...
Molecular & Computational biology
Jul 18, 2025
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44
Many proteins are capable of spontaneously rearranging themselves within cells to form molecular condensates—membraneless intracellular structures formed by one or multiple proteins—through a process known as liquid–liquid ...
Biotechnology
Jul 18, 2025
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26
Van Andel Institute scientists have developed an improved technique to comprehensively profile DNA methylation in single cells, an advance that will help researchers better study the role of epigenetics in cancer and other ...
Biotechnology
Jul 15, 2025
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21
A new study published in Cell has unveiled a first-of-a-kind optogenetic screening platform, developed by scientists at Integrated Biosciences, a biotechnology company integrating optogenetics, chemistry and AI to discover ...
Biotechnology
Jul 14, 2025
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41
Molecular glues, tiny molecules that connect one protein to another, are promising targets for pharmaceutical research. By linking a disease-related protein to one that triggers a cell's demolition and recycling pathways, ...
Using a high-throughput fluorescence microscopy system and machine learning algorithms, oxidative stress-related changes in protein localization have been mapped by researchers from Japan. Furthermore, a comprehensive database ...
Cell & Microbiology
Jul 11, 2025
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17
University of Cincinnati Cancer Center researchers looked billions of years into the past to learn more about the potential future of precision medicine.
Evolution
Jul 8, 2025
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27
To build proteins, cells rely on a molecule called transfer RNA, or tRNA. tRNAs act like protein-building couriers, where they read the genetic instructions from messenger RNA, mRNA, and deliver the right amino acids to ribosomes, ...
Biotechnology
Jul 7, 2025
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28
Professor Hirohide Saito and his research team have developed a new microRNA-responsive hybrid mRNA switch, enabling precise, tissue-specific control of protein expression and pushing the potential of mRNA-based therapeutics.
Biotechnology
Jul 7, 2025
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26
