Bioinformatics is a computational and analytical technique that applies algorithms, statistical methods, and database technologies to the acquisition, storage, processing, and interpretation of biological data, particularly large-scale omics datasets such as genomes, transcriptomes, and proteomes. It encompasses sequence alignment, gene prediction, variant calling, structural modeling, functional annotation, and systems-level network analysis. Bioinformatics pipelines integrate heterogeneous data types, automate quality control, and support reproducible research through workflow management and version-controlled code. As a technique, it enables hypothesis generation, biomarker discovery, and rational design in fields including molecular biology, genomics, pharmacology, and systems biology by transforming raw high-throughput experimental outputs into interpretable, quantitative biological insight.
Conformational changes in proteins are vital to their function yet remain challenging for state-of-the-art artificial intelligence, such as AlphaFold3, to predict. Researchers at the Institute for Molecular Science (IMS), ...
Biotechnology
Sep 5, 2026
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47
When a patient's DNA is read, it is compared with a reference version of the human genome. This allows geneticists and rare disease experts to look at a list of places where the patient's DNA differs. Most variations will ...
Biotechnology
Sep 3, 2026
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7
Single-cell RNA sequencing (scRNA-seq) is a method for measuring gene expression in individual cells, allowing observation of various cellular processes, including cell differentiation, the cell cycle and stimulus response, ...
Cell & Microbiology
Sep 1, 2026
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9
Researchers today announced AdaptiveFlow, an AI-informed platform that can virtually screen billions of drug-like molecules with a 1,000-fold reduction in computational costs over existing methods. Developed and validated ...
Biotechnology
Sep 1, 2026
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Researchers at Constructor University and Constructor Labs have developed BiteNetI, a deep-learning model that locates the binding sites of 14 biologically important ion types directly in three-dimensional protein structures. ...
Biotechnology
Sep 1, 2026
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11
Imagine doctors could understand exactly which cells caused a patient's cancer or whether pathogens contributed to the disease. They could then use the information to tailor a treatment plan to the patient's specific cancer. ...
Biotechnology
Aug 28, 2026
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26
A protein's function is determined by its structure, and structure—the way a protein folds—is determined by its sequence of amino acids, the building blocks of proteins.
Biotechnology
Aug 27, 2026
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52
In a study recently published in Nature Communications, researchers from Berlin, Potsdam, and Jena present a new method for analyzing the epigenome. The machine-learning method identifies differentially methylated DNA regions ...
Biotechnology
Aug 25, 2026
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82
Precise activation of tens of thousands of genes is critical for healthy development and growth. Specialized segments of our DNA are responsible for carefully orchestrating genetic sequences that result in the production ...
Biotechnology
Aug 22, 2026
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644
Modern biology research can now generate valuable data on an unprecedented scale. But there is one major obstacle: making sense of these complex high-dimensional datasets. A team at the University of Basel, Switzerland, has ...
Biotechnology
Aug 21, 2026
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