Packaging process for genes discovered

Scientists at Penn State University have achieved a major milestone in the attempt to assemble, in a test tube, entire chromosomes from their component parts. The achievement reveals the process a cell uses to package the ...

Is the shape of a genome as important as its content?

If there is one thing that recent advances in genomics have revealed, it is that our genes are interrelated, "chattering" to each other across separate chromosomes and vast stretches of DNA. According to researchers at The ...

Researchers determine the composition of centromeric chromatin

The Stowers Institute's Gerton Lab has provided new evidence to clarify the structure of nucleosomes containing Cse4, a centromere-specific histone protein required for proper kinetochore function, which plays a critical ...

A yeast cancer model for mapping cancer genes

Researchers have devised a scheme for identifying genes in yeast that could lead to the identification of new cancer genes in humans. The study is published online this week in the open-access journal PLoS Biology.

Cohesin jigsaw begins to fit

The essential chromosomal protein complex cohesin has crucial roles in sister chromatid cohesion, DNA repair and transcriptional regulation. Despite its conserved function, cohesin's disparate association patterns in different ...

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