News tagged with xist

Tags on RNA silence X chromosome in females

The addition of a chemical tag on an RNA molecule is the critical switch that inactivates one X chromosome in every cell, ensuring healthy development in all female mammals, according to new research by Weill Cornell Medicine ...

dateSep 19, 2016 in Biotechnology
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Hushing the X chromosome

Early in the development of female embryos, a crucial event occurs in all cells: An X chromosome is silenced. Whereas males have only one X chromosome, females have two—which means they can have twice as many proteins generated ...

dateAug 08, 2016 in Biotechnology
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How an RNA gene silences a whole chromosome

Researchers at Caltech have discovered how an abundant class of RNA genes, called long non-coding RNAs (lncRNAs, pronounced link RNAs) can regulate key genes. By studying an important lncRNA, called Xist, the scientists identified ...

dateApr 27, 2015 in Biotechnology
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Scientists unveil sex-linked control of genes

Many proteins interact with an RNA molecule called Xist to coat and silence one X chromosome in every female cell. Learning how genes are targeted and silenced may help researchers studying sex-specific diseases.

dateApr 03, 2015 in Biotechnology
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Revealing a missing link

When it comes to genes, it’s definitely possible to have too much of a good thing. Accordingly, mammalian females have a mechanism that randomly inactivates one of the two X sex chromosomes within each somatic cell nucleus, ...

dateNov 12, 2010 in Cell & Microbiology
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Aurora B answers an XIST-ential question

Early in development, mammalian female cells counteract their double dose of X chromosomes by coating one of them with a large RNA named XIST. The RNA binds to the same X chromosome from which it is transcribed and initiates ...

dateAug 24, 2009 in Cell & Microbiology
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