Discovery of a cellular uptake pathway for larger drug molecules

Recent findings by UCSF and Arc Institute scientists open up new possibilities for overcoming a fundamental challenge in drug discovery. There can be a tradeoff between optimizing a drug's key-in-a-lock fit with its target ...

A new control system for synthetic genes

Using an approach based on CRISPR proteins, MIT researchers have developed a new way to precisely control the amount of a particular protein that is produced in mammalian cells.

Researchers develop new tool for targeted cell control

Thanks to new RNA vaccines, we humans have been able to protect ourselves incredibly quickly from new viruses like SARS-CoV-2, the virus that causes COVID-19. These vaccines insert a piece of ephemeral genetic material into ...

When dangerous toxins teach fundamental biology

"What our work shows is how a complex in the center of the cell, the ER-Golgi interaction region, controls plasma membrane cholesterol, which is essential for many cellular functions, if not essential for multicellular life," ...

Determining how and why cells make decisions

Cells are constantly making decisions that lead to differentiation. For instance, cells in an embryo make a series of decisions that determine whether they will become neurons in some cases and muscle cells in others. How ...

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