Sex, genes, the Y chromosome and the future of men

The Y chromosome, that little chain of genes that determines the sex of humans, is not as tough as you might think. In fact, if we look at the Y chromosome over the course of our evolution we've seen it shrink at an alarming ...

Scientists use CRISPR technology to insert sex-determining gene

Scientists at the University of California, Davis, have successfully produced a bull calf, named Cosmo, who was genome-edited as an embryo so that he'll produce more male offspring. The research was presented in a poster ...

Evolution of diverse sex-determining mechanisms in mammals

Scientists historically have argued that evolution proceeds through gradual development of traits. But how can incremental changes apply to the binary switch between two sexes, male or female? Researchers at Case Western ...

Unravelling the secrets of maleness

New research has identified the key to becoming male is an enzyme that "unravels" DNA to trigger male development of the embryo, a discovery that may give greater insight into intersex disorders.

How to be a male without the Y chromosome

Hokkaido University researchers have revealed that key sex-determining genes continue to operate in a mammalian species that lacks the Y chromosome, taking us a step further toward understanding sex differentiation.

Researchers identify female sex determining gene in mice

Researchers at the Francis Crick Institute and the Université Cote d'Azur, together with other labs in France and Switzerland, have identified a gene which is an early determining factor of ovary development in mice.

Scientists identify key event for sex determination

Scientists at the Institute of Molecular Biology (IMB) in Mainz have identified a protein essential for initiating the development of male sex organs. Loss of the gene Gadd45g results in complete sex reversal of male mice, ...

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