The Broad Institute and MIT scientists who first harnessed CRISPR for mammalian genome editing have engineered a new molecular system for efficiently editing RNA in human cells. RNA editing, which can alter gene products ...
Biotechnology
Oct 25, 2017
2
762
The Y chromosome, which is found only in males, is difficult to decode even with the latest sequencing technologies. Among evolutionary biologists, the question as to which genes lie on the male sex chromosome and where they ...
Biotechnology
Oct 25, 2017
0
22
So much of what happens inside cells to preserve health or cause disease is so small or time-sensitive that researchers are just now getting glimpses of the complexities unfolding in us every minute of the day. UNC School ...
Cell & Microbiology
Aug 24, 2017
0
218
High-resolution crystal structure reveals a new pathway for RNA during a nontraditional form of transcription—the process by which RNA is produced from a DNA template. Caught during the act of reiterative transcription, ...
Cell & Microbiology
Aug 22, 2017
0
6
A novel approach developed at the Friedrich Miescher Institute for Biomedical Research (FMI) has allowed scientists in Dirk Schübeler's group to dissect and quantify the individual steps of transcription initiation. Unexpectedly, ...
Cell & Microbiology
Jul 26, 2017
0
15
Control of RNA lifespan is vital for the proper functioning of our cells. Marc Bühler's group at the Friedrich Miescher Institute for Biomedical Research (FMI) has discovered a novel mechanism determining the fate of RNA ...
Cell & Microbiology
Jun 5, 2017
0
12
Single-celled plankton known as dinoflagellates are shown to cope with stress using an unexpected strategy of editing their RNA rather than changing gene expression levels.
Biotechnology
Apr 17, 2017
0
3
Octopuses, squid, and cuttlefish often do not follow the genetic instructions in their DNA to the letter. Instead, they use enzymes to pluck out specific adenosine RNA bases (some of As, out of the As, Ts, Gs, and Us of RNA) ...
Biotechnology
Apr 6, 2017
2
2173
Sequencing messenger RNA molecules from individual cells offers a glimpse into the lives of those cells, revealing what they're doing at a particular time. However, the equipment required to do this kind of analysis is cumbersome ...
Biotechnology
Feb 13, 2017
0
7
Yukiko Shimada, Fabio Mohn, and Marc Bühler at the FMI elucidated an important mechanistic detail of small RNA mediated chromatin silencing. They showed in fission yeast that the small RNA in the RNA induced silencing complex ...
Cell & Microbiology
Dec 22, 2016
0
8
