Dissecting the mechanism of protein unfolding by SDS

Researchers at the University of Illinois at Urbana-Champaign have used molecular dynamics simulations to understand how sodium dodecyl sulfate causes protein unfolding. SDS is commonly used in labs to separate proteins and ...

SLAC X-ray laser used to probe biomolecules to individual atoms

An international team led by SLAC National Accelerator Laboratory has proved how the world's most powerful X-ray laser can assist in cracking the structures of biomolecules, and in the processes helped to pioneer critical ...

Simplicity is crucial to design optimization at nanoscale

MIT researchers who study the structure of protein-based materials with the aim of learning the key to their lightweight and robust strength have discovered that the particular arrangement of proteins that produces the sturdiest ...

Looking for hidden states of the COVID-19 spike protein

The virus wreaking havoc on our lives is an efficient infection machine. Comprised of only 29 proteins (compared to our 400,000), with a genome 1/200,000 the size of ours, SARS-CoV-2 is expertly evolved to trick our cells ...

Fuzzy molecular threesome is basis of gene expression

Specific nuclear proteins act as a glue to pack genetic material in an absurdly small space in the human body. Proteins "gluing" DNA are called linker histones, and hold their secret in their electric charge. They are strongly ...

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